In the brooding stage, due to weak chicks and imperfect organ development, the external environment and feeding management requirements are high. The temperature can not be high, the density can not be small, and the ventilation can not be bad. In the case of the chicks that I received, there were relatively many diseases caused by improper feeding and management.
Among many factors, maintaining the right temperature and air quality in the home is a top priority. In order not only to maintain a good temperature inside the house, but also to save fuel, farmers are afraid to open the curtain, and did not dare to open the window, leading to severe ventilation in the house, damage the respiratory mucosa of the chicks, and induce respiratory diseases.
This type of respiratory disease in chicks is most likely to develop at the earliest days of five or six days, and it also begins to develop on more than ten days. From the beginning of illness to death, it lasted for three or four days to ten days. At the beginning of the disease, the eye's conjunctiva can be seen to be flushed, shy and tearful. There are abnormal respiratory sounds such as sneezing, throwing nose, and coughing. Later, there was a mouth-opening phenomenon in the flock but no sound was given and death would occur when the condition worsened. According to the introduction of professional households, common cases of sudden death of mentally depressed chickens, with varying degrees of mortality, depend mainly on the extent of the disease and the improvement of the feeding environment.
In the process of pathological necropsy, dead chickens are generally or better in body condition, with less incidence of poor health. The characteristic necropsy is the pathological changes of the respiratory system. The nasal cavity, larynx, and tracheal mucosa are all catarrhal inflammation. There is serous exudation. There are yellow long strips of sticky phlegm on the upper or lower part of the trachea, and some are warmed by charcoal. The formation of black storks shows the degree of air pollution in the brooding houses. The long course of the disease has yellow cheese-like embolisms in the bronchus of the bifurcation at the lower end of the trachea. The lungs are congested, and the liver and kidney are swollen and dark. The appearance of the entire intestine was reddening, diffuse mucosal hyperemia, and local irregular bleeding.
Once such diseases are discovered, they can generally be controlled by vigorously improving the feeding environment and actively treating symptomatic medications. Clinically, the principle of treatment is to eliminate pathogenic incentives on the one hand, and on the other hand to use anti-inflammatory phlegm, pharynx, expansion of the trachea drugs. After 3 to 5 days of medication, the improvement of the feeding situation can be basically restored.
During the brooding stage, we can draw warnings and properly handle the contradiction between temperature and ventilation to improve the economic benefits of breeding.
API Powder is fully defined in ICH Q7A as any substance or mixture of substances intended for use in the manufacture of pharmaceutical products and, when used in pharmaceutical products, as an active ingredient of pharmaceutical products. Such substances have pharmacological activities or other direct effects in the diagnosis, treatment, symptom relief, management or prevention of disease, or can affect the function or structure of the body. The active ingredient of a medicine. Only when an API is processed into a pharmaceutical preparation can it become a medicine for clinical application.
According to its source, apis are divided into chemical synthetic drugs and natural chemical drugs.
Chemical synthetic drugs can be divided into inorganic synthetic drugs and organic synthetic drugs. Inorganic synthetic drugs are inorganic compounds (very few are elements), such as aluminum hydroxide and magnesium trisilicate for the treatment of gastric and duodenal ulcer, etc. Organic synthetic drugs are mainly made of basic organic chemical raw materials, through a series of organic chemical reactions and drugs (such as aspirin, chloramphenicol, caffeine, etc.).
Natural chemical drugs can also be divided into biochemical drugs and phytochemical drugs according to their sources. Antibiotics are generally produced by microbial fermentation and belong to the category of biochemistry. In recent years, a variety of semi-synthetic antibiotics are the combination of biosynthesis and chemical synthesis products. Among apis, organic synthetic drugs account for the largest proportion of variety, yield and output value, which is the main pillar of chemical pharmaceutical industry. The quality of the API determines the quality of the preparation, so its quality standards are very strict. All countries in the world have formulated strict national pharmacopoeia standards and quality control methods for the widely used APIS.
Specific API after processing -- pharmaceutical preparations
The term API is used mainly in relation to the finished product. Mainly raw materials obtained by chemical processing means, supply raw materials for the production of finished drugs. For example, cefpirome sulfate for injection is a drug, then cefpirome sulfate is an API
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