Pharmacological effects
[Influence on blood system]:
Dangxiang is a traditional Chinese medicine for activating blood circulation. Experiments have shown that the hyperviscosity of blood stasis syndrome caused by the injection of high molecular dextran can significantly reduce the viscosity of whole blood, especially the effect of reducing whole blood viscosity at high shear rate. It can also reduce the plasma viscosity, but has no significant effect on the aggregation of red blood cells. It also reduces the blood lipids. It may reduce the blood viscosity of blood stasis syndrome animal may be related to its lipid-lowering effect, and its mechanism of lowering blood lipids is related to Can inhibit HMG coenzyme A reductase related. Experiments using rabbit kidney microsomal fractions as prostaglandin synthetases showed that 8 compounds from the chloroform-soluble fraction of D. osmoticum extracts had strong prostaglandin synthesis inhibitory effects. Some ingredients can also significantly inhibit platelet aggregation. The eight compounds that inhibit the synthesis of prostaglandins are: 2-hydroxy-3,4-dimethoxybenzoic acid methyl ester, hydroxy-insoluble Dalbergia sulphosene, iso-micro-convex swords Susa solidene, racemic micro convex sasha Phenol, formononetin, (3R) donkey herbophenol, medicarpin, and levorotatory 9-O-methylnoniol pea polidiol. The first three compounds all significantly inhibit platelet aggregation.
[Influence on the cardiovascular system]:
Dangxiang is one of the constituents of Guanxin II prescription. Experiments have shown that the single-flavor reduction can significantly promote the restoration of blood flow in experimental mesenteric microcirculatory disorders in mice and the recovery of microarteries after contraction and recovery of local microcirculation. Its anti-adrenaline-induced micro-artery contraction is stronger, and it has a weaker effect on delayed blood flow. The significant antihypertensive effect of Guanxin II was achieved, in which the deodorant functioned by inhibiting the receptor of angiotensin II. Salvia miltiorrhiza injection can also reduce the portal vein pressure, the mechanism may be to expand the portal vein venules and villous capillary network, but not against the increase in portal vein pressure caused by histamine.
ã€Sedative Anti-panic Action】:
The ethanol extract of Dangxiang significantly reduced the spontaneous activity of mice, significantly prolonged 53%, 100mg/kg, 250mg/kg, respectively, by 83% and 102%, 500mg/kg thp ta 355%, but the dose reached 5g/kg It also does not cause mouse hemp mg/kg season incense gavage, can significantly inhibit the incidence of mice, electroconvulsions, 500mg/kg agent can significantly against the smoke and seizures, but the role of pentylenetetrazol convulsions Weak, ineffective for poisonous and alkaline convulsions.
Analgesic effect:
The 500mg/kg fragrant irrigation can significantly prolong the pain reaction time of the hot plate method in mice, indicating that there is analgesic effect, but the acetic acid writhing test 1000mg/kg did not show a significant inhibitory effect.
[Other effects]:
Fragrant can inhibit cholecystokinin receptor and purine invertase.
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