Vitamin B6 is also known as pyridoxine. It is a water-soluble vitamin that is easily destroyed by light or alkali and is not resistant to high temperatures. A B vitamin containing pyridoxine or pyridoxal or pyridoxamine.
Clinical application of vitamin B6
1, rescue isoniazid poisoning
The use of 1g of isoniazid per serving can be slowly intravenous vitamin B61g. If you do not know the amount of poisoning, you can slowly intravenous vitamin B65g, which lasted 3 ~ 5min, when the poor can be repeated intervals of 5 ~ 20min until the convulsion stopped, consciousness recovery. The insufficient amount of vitamin B6 is the main reason for rescue failure.
2, treatment of anemia
Vitamin B6 is a coenzyme of δ-amino-γ-levulinic acid synthase, and this enzyme is a rate-limiting enzyme for synthetic hemoglobin, so it can be used as an adjuvant therapy for preventing anemia.
3, treatment of leukopenia
Vitamin B6 is involved in the metabolism of amino acids and fats, stimulates leukocyte production, and can be used to treat leukopenia. Usually daily oral 30 ~ 60mg, also available vitamin B650 ~ 100mg added 5% glucose solution 20ml intravenous injection.
4, treatment of mental retardation
One of the causes of the disease is the mutation of genes. The arrangement of amino acids on the DNA molecule changes the transmission of genetic information, causing defects in the activity of the enzyme or weakening, resulting in various metabolic disorders. Vitamin B6 can participate in the metabolism of amino acids and the conversion of metabolic enzymes, and has the effect of correcting various metabolic abnormalities. According to clinical observation, retarded mental retardation, taking vitamin B6 every 1 month for a course of treatment, rest 1 week after the second course of treatment, the first 2 to 4 courses of treatment, the intelligence has been significantly improved.
5, treatment of oral ulcers
Vitamin B6 100mg / time, 3 times / d oral or 100mg added 5% GS20ml intravenously, generally 3 to 4 days Jiyu.
6, treatment of arteriosclerosis and thromboembolic disease
Vitamin B6 can promote the conversion of linoleic acid into arachidonic acid, and the latter esters combined with cholesterol can be easily transported and metabolized. In addition, vitamin B6 can inhibit platelet function and fibrin formation, so it can lower cholesterol and prevent thrombosis. The usage is 50 mg/d intramuscularly.
7, back to milk
From 2 to 6 days of fertility, medication 5 to 6 days, 0.2g/time, 3 times/d orally, 10 to 12 hours effective, its inhibition of milk secretion rate of 95% faster than the effective estrogen, the effect is good, and no side effect. The principle of action is related to the promotion of dopamine production in the brain, thereby stimulating dopamine receptors and reducing pituitary prolactin secretion.
8, treatment of Parkinson's syndrome
Can significantly reduce the tremor, began intramuscular injection of 50mg / d, then gradually increase 50mg / d, until 0.3 ~ 0.4g / d, 12 to 15 days for a course of treatment, the total amount of 3 ~ 4g. The principle of action is related to the increase of dopamine concentration in the brain, thereby agonizing the striatal dopamine receptor.
9, treatment of tetanus
Tetanus exotoxin inhibits the release of gamma-aminobutyric acid and glycine, and vitamin B6 is resistant to delirium by promoting the synthesis of gamma-aminobutyric acid. It is used in combination with penicillin and TAT, and is controlled early, with a mortality rate of only 15%. The mortality rate of TAT + penicillin + sedatives is as high as 60%. The use of vitamin B6120mg / d, 2 oral or 100mg / d intramuscular injection.
10, treatment of gestational diabetes
Pregnant women easily lack of vitamin B6 caused by tryptophan metabolism, resulting in yellow uric acid - insulin complex, the latter's hypoglycemic effect by half, it caused gestational diabetes. Treatment with vitamin B6 at 100 mg/d for 2 weeks significantly reduces blood glucose and changes the glucose tolerance curve.
11. Depression caused by birth control pills
The estrogen-like effects of contraceptives can reduce the concentration of pyridoxal phosphate, and increase the body's requirement for vitamin B6 and alter the metabolism of cerebro-amine, so it is easy to cause psychosis. After giving vitamin B6, the depressive symptoms can be improved.
12, enhance immunity and cancer
Vitamin B6 deficiency damages cells and affects humoral immune function. Vitamin B6 can improve immunity and have certain anti-cancer effects. The latter may be related to reducing carcinogens in vivo.
13 treatment of vitamin C caused by oxalate stones
Vitamin C is metabolized to oxalic acid, and then forms oxalate stones with Ca2+ and Mg2+. Therefore, taking vitamin C1g or more daily should be supplemented with vitamins B650 to 100 mg anti-calculus, because vitamin B6 is effective for urinary calculi consisting mainly of oxalate.
14, vitamin B6-dependent convulsions
The disease is an autosomal recessive genetic disease. Vitamin B6 cannot bind to its enzyme protein, glutamic acid decarboxylase, and GABA produced by glutamic acid is reduced, causing convulsions. According to clinical observations, seizures, intravenous vitamin B6100mg / day, the attack stopped after a few minutes.
15, asthma effect
Asthma in infants is a common symptom of respiratory diseases, and asthma is the focus and difficulty of treatment. According to clinical observation of 120 cases of asthmatic children with intravenous injection of vitamin B615 ~ 20mg/kg, 2 or 3 times a day, 4 days for a course of treatment, the total efficiency of 84%. The mechanism of action may be: (1) Dopamine decarboxylase catalyzes the synthesis of epinephrine from tyrosine, which is a vitamin B6 dependent enzyme. Epinephrine synthesis is reduced when vitamin B6 is deficient, and bronchial spasm occurs. (2) Increased serotonin levels in blood and sputum of some children with asthma may have vitamin B6-associated tryptophan metabolism disorder. After treatment with high-dose vitamin B6, the tryptophan load test returns to normal and asthma attacks improve. .
16, treatment of carpal tunnel syndrome
The disease is related to vitamin B6 deficiency. According to clinical observations, patients taking vitamin B6300mg daily for 4 weeks, the symptoms can be completely relieved after 2 weeks.
People who need vitamin B6 supplements:
1, the elderly: the elderly susceptible to chronic wasting disease or intestinal malabsorption, easy to lack of vitamin B6, there will be signs of anemia, decreased resistance and other symptoms. It is recommended to supplement 50 mg of vitamin B6 daily to enhance immunity.
2, women with premenstrual syndrome: daily intake of 50-250 mg of vitamin B6, can effectively relieve women before menstruation tension, anxiety, emotional ups and downs, breast tenderness and other symptoms.
3, smokers: smoking will reduce the utilization of vitamin B6, easily lead to the lack of vitamin B6 in the body, it is best to adequate supplement.
4, alcoholics: As alcohol will reduce vitamin B6 content in the body, resulting in low levels of vitamin B6 in the body, it is recommended to add 15-20 mg of vitamin B6 daily intake.
5, the proportion of dietary protein is high: due to vitamin B6 help break down the protein, can be too much protein into the body's nutrients, to avoid excessive accumulation in the body and cause chronic diseases.
6, pregnant women and breastfeeding women: It is recommended to take 30 mg of vitamin B6 daily, can reduce the symptoms of finger phalanges and finger joint pain.
7. Patients with Heart Disease: Vertrisol B6 has some help in maintaining heart health and can reduce the chance of heart attack.
8, women taking contraceptive pill: taking oral contraceptives will make the blood vitamin B6 content is low, it needs appropriate supplements. Long-term oral contraceptives can also increase the metabolic rate of tryptophan and increase the demand for vitamin B6.
9, allergic people: Vitamin B6 can help produce antibodies, can enhance the skin's anti-allergic ability.
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