Molecular Pharmacology: Breast cancer, new treatment for pancreatic cancer
January 27, 2015 Source: Bio Valley BIOON
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Recently, researchers at the Kriss Institute (TSRI) in Florida, USA, discovered a new synthetic compound called SR1848. This compound can effectively slow the development of pancreatic cancer and breast cancer by inhibiting the synthesis and activity of a tumor-associated protein, "LRH-1". The study was published in the February issue of Molecular Pharmacology.
LRH1 is considered a risk factor for breast cancer because it is involved in hormone synthesis and cholesterol metabolism. Recently, LRH-1 has also been shown to promote the development of intestinal and pancreatic cancer. Overexpression of LRH-1 has been shown to promote tumor invasion and metastasis.
The new compound SR1848 synthesized by the research team can directly inhibit the activity of LRH-1. When cells were transfected, SR1848 inhibited the expression of LRH-1-driven reporter genes, and the production of two other cyclins Cyclin-D1 and E1, which are dependent on LRH-1 expression, was also significantly reduced, thereby inhibiting cell proliferation. . Experiments have shown that SR1848 can induce rapid translocation of LHR-1 already produced in the nucleus to the cytoplasm. The level of nuclear in the cells of LHR-1 was significantly reduced 4 hours after SR1848 treatment.
The results indicate that SR1848 can inhibit the proliferation of LRH-1 expressing cancer cells such as breast cancer cells and pancreatic cancer cells, which provides a new possibility for the treatment of breast cancer and pancreatic cancer. On the other hand, because it does not significantly affect cells that do not express LRH-1, this may mean some potential side effects.
Original link: http://news.bioon.com/article/6665233.html
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