Release date: 2016-10-18
With the support of the National Key Research Program and the National Natural Science Foundation for Major Infectious Diseases and Liver Cancer, the research team led by Professor Qin Lunxiu, Director of General Surgery, Huashan Hospital, Fudan University, and the National Institutes of Health (NIH) research team. After years of hard research, the new mechanism of liver cancer metastasis has been discovered. The results have been published in the newly published internationally renowned oncology journal Cancer Cell. Another famous journal, Cancer Discovery, is The study was assigned a special review to express affirmation and concern, which will help to more accurately predict and individualize interventions in tumor metastasis and recurrence, while the in vivo Golgi-associated protein "GOLM1" may be a potential marker for liver cancer metastasis. Treatment targets, and future development of inhibitors targeting "GOLM1" will likely control the metastasis of liver cancer.
According to Professor Qin Lunxiu, tumor metastasis is the leading cause of cancer, especially in patients with liver cancer. In this process, cancer cells spread to other organs and adapt to the new environment. In the process of tumorigenesis and metastasis, various "receptors" on the surface of cells in the body stimulate the key downstream signaling pathways related to tumor cell proliferation, invasion and metastasis by receiving various growth factors from the outside, which leads to tumor metastasis. The abnormal "exciting" of "EGFR receptor" is a key factor in promoting cancer progression and metastasis. In normal cells, the "EGFR receptor" will be relatively "cool" during its binding to its ligand, and will not continue to "excite". In tumors, after the "EGFR receptor" binds to its ligand, it is "endonized" by the cell. Most of them will be transported to the trans-Golgi apparatus (an organelle that plays a major role in secretion), and then circulate to the cell membrane, thereby evading degradation, so that the downstream signals related to the tumor continue to "excite", eventually leading to tumor cell proliferation, invasion and Transfer. Although the phenomenon of "EGFR receptor" recycling leading to tumor metastasis has attracted the attention of scientists all over the world, its mechanism remains unclear, especially the role of the Golgi-related pathway has not been reported. .
Professor Qin Lunxiu's research team solved the mystery of liver cancer metastasis. Using the "whole genome" technology to analyze the specific genes of hepatocellular carcinoma metastasis, it was found that the Golgi-associated protein "GOLM1" in liver cancer cells and the liver in the liver Metastasis is closely related to poor prognosis of patients; further mechanism studies have found that GOLM1 promotes the process of liver cancer metastasis by regulating the intracellular "EGFR receptor" recycling pathway, that is, by regulating the "EGFR receptor" and other intracellular redistribution , contributed to the metastasis of cell cancer.
Source: Medical Forum Network
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