The efficacy of Banlangen

Radix is ​​effective:

1, to improve immune function: mice intraperitoneal injection of Radix isatidis polysaccharide 50mg/kg, can significantly promote the immune function of mice, showed: can significantly increase the spleen weight of normal mice. The total number of white blood cells and lymphocyte counts significantly inhibited the decrease of spleen index, the total number of white blood cells, and the number of lymphocytes in mice with immunosuppression caused by hydrocortisone; significantly enhanced normal and cyclophosphamide induced by dinitrochlorobenzene. Delayed hypersensitivity reaction induced by immunosuppressive mice; Increased percentage of ANAE-positive lymphocytes in peripheral blood of normal mice and apparently counteracted the immunosuppressive effects caused by hydrocortisone; but in vitro experiments with Isatis root polysaccharides induced by Concanavalin A No significant enhancement of the lymphocyte reaction was observed in spleen cells of mice. In addition, Radix isatidis polysaccharide can significantly enhance the function of antibody-forming cells and increase the rate of carbon particle clearance for intravenous injection in mice.

2. Antibacterial and antiviral effects: Indigo root has effects on various bacteria. Aqueous extracts have inhibitory effects on Bacillus subtilis, Staphylococcus aureus, Staphylococcus aureus, Escherichia coli, Salmonella typhi, Paratyphoid fever parasites, dysentery (Shiga, Freund's), enterobacteriaceae, etc.; acetone extracts are also similar Effect, and effective for hemolytic streptococcus (all agar plate method). The antibacterial effect against meningococcal group A was similar to garlic and honeysuckle. The antibacterial and antiviral active ingredients of Radix Isatidis and Folium Isatidis are thought to be aphid. Experiments have shown that earthworms have no antibacterial effect in vivo and in vitro; the antiviral effect in vitro is not prominent; and excretion in the body is fast, so it is considered that it has no obvious physiological and antibacterial activity. Its active ingredients are yet to be studied.

3. Anti-tumor effect: Injected indirubin 200 mg/kg to rat W256 solid tumor and mouse Lewis lung cancer for 6-7 consecutive days, the inhibition rate of rat W256 solid tumor was 47-50% and 50- At 58%, when the subcutaneous injection was reduced to less than 100 mg/kg daily, its inhibitory effect was not significant. Indirubin 500mg/kg gavage, the inhibition of W256 solid tumor in rats was 23-33%, the inhibition rate of mouse sarcoma 180 is about 30%. Indirubin can prolong the survival time of lymphoblastic leukemia L7212 mice by 20%. In addition, the mouse spermatogonia test showed that indirubin can not specifically inhibit the type B spermatogonia and sperm cells.

4, detoxification: According to reports, the dog with Banlangen, Coptis powder and Veratrum with the service (each 2.0g/kg), can solve the reed poison, reduce mortality; if Veratrum poisoning after use, it is invalid; The use of Banlangen or Coptis powder alone is not effective.

5, the role of leukemia: pharmacological studies have initially shown that indirubin has a role in the destruction of leukemia cells. From the ultrastructural morphology, under the effect of Indirubin, degenerated and necrotic cells are mostly swollen and soluble necrotic. It was found that indirubin can enhance the phagocytic activity of the mononuclear macrophage system in animals. The mononuclear macrophage system plays a role in the body's immune response, so the anti-cancer effect of indirubin may be related to improving the body's immunity.