New drugs can effectively block 90% of melanoma metastasis
January 11, 2017 Source: Bio Valley
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];In a recent study published in the international journal Molecular Cancer Therapeutics, researchers from Michigan State University found that a new type of potential drug could reduce the spread of melanoma cells by up to 90%. This artificial small molecule compound can target the activity of genes that produce RNA molecules and specific proteins in melanoma tumor cells. Special gene activities (or transcriptional processes) can induce melanoma spread, but new compounds developed by researchers can It is effectively inhibited, and so far, few pharmaceutical compounds have been able to achieve this goal.
Researcher Richard Neubig said that the development of small molecule drugs that block gene activity is a huge challenge for us because gene activity can act as a signaling mechanism that is important for the progression of melanoma; One of the compounds developed is the ability to potentially treat a variety of scleroderma and, of course, to effectively treat many types of cancer. Scleroderma is a rare, lethal autoimmune disease that causes skin tissue and multiple organ sclerosis. The same mechanism of fibrosis or skin thickening in scleroderma often induces the production and spread of cancer.
Nowadays, small molecule drugs account for more than 90% of the drug market. Researchers believe that this study is only an early discovery. The new small molecule drugs they developed can effectively resist lethal skin cancer. It is estimated that this skin cancer is not a year. About 10,000 people will die. Appleton said that melanoma is a fatal skin cancer. There are about 76,000 new patients each year in the United States. The disease is so lethal because it spreads rapidly throughout the body and attacks distant organs in the body, such as Brain and lungs, etc.
The researchers note that this novel compound blocks the transcription of a protein called melanin-related transcription factors (MRTFs) in melanoma cells, and that these trigger proteins can be called another RhoC (Ras The protein of the source C) is opened, and the RhoC protein is present in the signaling pathway, which can promote the rapid spread of the disease in the body. The new compound can reduce the metastasis of melanoma from 85% to 90%, and the researchers have found that this potential drug can significantly reduce tumor metastasis in the lungs of mice injected with human melanoma cells.
Researcher Neubig said that we used intact melanoma cells to screen for chemical inhibitors, which may help us find compounds that effectively block the RhoC pathway. Blocking the entire pathway can help researchers discover that MRTF signaling proteins can be used as novel drug targets. Explaining which pathways this pathway is open to is critical for later development of new compounds, as this may help the researchers determine which patients are most likely to benefit from ingesting the drug, and when the pathway is open, the new compound It effectively shuts down the growth of melanoma cells and inhibits disease progression, so activation of MRTF proteins may serve as a novel marker to help determine the risk of melanoma in patients.
The researchers point out that if the disease is detected early, the risk of death is only 2%, and if it is found late, the mortality rate will reach 84%. Most of the people who die from melanoma are due to the spread of the disease. The novel compounds discovered by the researchers in this paper can potentially block the metastasis of cancer and increase the survival rate of patients.
Disposable Piercing Guide - WPTC10
Product Description
Disposable surgical medical products refer to items used in surgical operations, which are discarded after one use. These products are used to maintain a sterile environment and prevent the spread of infection during surgery.
Some common disposable surgical medical products include:
1. Surgical masks: used to cover the mouth and nose of medical staff during operations to prevent the spread of germs.
2. Surgical gowns: Medical staff wear these to protect their clothing from contamination during surgery.
3. Surgical Gloves: Healthcare providers wear these gloves to protect their hands from contamination during surgery.
4. Surgical Drape: Used to cover the patient and create a sterile field around the surgical site.
5. Surgical needles: Used to suture incisions and wounds during surgery.
6. Scalpel blades: These are used to make incisions during surgery.
7. Surgical Forceps: Used to grasp and manipulate tissue during surgery.
8. Surgical catheters: These catheters are used to drain fluids from the body during surgery.
Overall, single-use surgical medical products are critical to maintaining a sterile environment and preventing the spread of infection during surgery.
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