Release date: 2016-07-13
Professor Gao Hua of Tongji University found a gene called TM4SF1 that promotes the metastasis of breast cancer to multiple organs. Related research papers were recently published in the journal Cell. Cutting off and blocking the expression of this gene may be the primary target for the treatment of breast tumor metastasis recurrence. "Our targeted treatment research has achieved good results." Gao Hua said.
Recurrence of tumor metastasis is the most direct cause of death in most cancer patients. In the early stage of breast cancer, tumor cells will leave the primary site and eventually “sow grow†into fatal metastatic lesions in multiple distal organs such as lung, bone and brain. Although tumor metastasis recurrence has important clinical significance, the related research is very weak, especially whether the presence of core genes in the process of tumor metastasis to multiple target organs is still unclear.
The human body has a protein that spans the lipid bilayer, also known as a transmembrane protein. TM4SF1 is an evolutionarily specific member of the four-pass transmembrane protein family that is up-regulated in a variety of tumors such as lung cancer, colorectal cancer, breast cancer, and ovarian cancer. Over the years, Gao Hua's research team has used mouse models as an in vivo screening tool to establish a high-throughput, genome-wide, and functionally relevant genetic screening platform to search for tumor metastasis and recurrence with breast cancer, lung cancer, and rectal cancer. Directly related molecules and their cellular and molecular mechanisms. In 2014, the team found that TM4SF1 plays a very important role in both normal and cancer stem cell self-renewal.
On this basis, the research team continued to use immunohistochemistry to analyze tissue microarrays of 147 patients with complete clinical information breast cancer, and found that TM4SF1 gene was up-regulated in breast cancer patients, and the survival time of patients was significantly shortened; On the contrary, the survival period is significantly prolonged. Similar results were obtained by analyzing 3455 breast cancer primary and metastatic tumor tissues by computer bioinformatics.
Gao Hua said that according to the strength of TM4SF1 gene expression, the length of time for tumor metastasis in breast cancer patients can be predicted. "At present, we are working with domestic related companies in accordance with the ideas of translational medicine, and research on monoclonal antibodies and small molecule compounds is progressing well and the results are good."
Source: Guangming Daily
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