Pharmacological effects
1. The main effect of the central nervous system is analgesic effect, its analgesic ingredients are evodiamine, rutacarpine, iso-evodiamine and evodilactone. Intravenous injection of 10% ethanol extract of Evodia can increase the body temperature of rabbits, and it can also increase the threshold of electrical stimulation of the mouth muscle contracture induced by rabbit dental pulp, and its effect intensity is equivalent to that of aminopyrine. Wuzhi decoction 5g/kg and 20g/kg can significantly delay the pain response time, and can remain for 2.5 hours. Oral administration of Evodia has a vomiting effect, and the same as ginger, the antiemetic effect can be strengthened. However, there are also reports that Wuqi decoction and acetone extract are given to the dogs, respectively, and the vomiting caused by 4% copper sulfate has no antiemetic effect.
2. Effect on the cardiovascular system Evodiamol - water extract 0.03 ~ 0. 24g/kg intravenous injection of anesthesia to produce a dependent boost effect and increase the contractility of the diaphragm, but tetraethylamine can not be antagonistic. 4. Intraperitoneal injection to conscious rats also induces pressure increase. Both bilateral nephrectomy, phentolamine, or propranolol significantly reduced the pressure-increasing effect. Experiments showed that: Wuqi decoction, granules and distillate, intravenous injection and intragastric administration have significant antihypertensive effect, and there is a dose-dependent, antihypertensive duration is longer, generally more than 3 hours, no significant effect on blood pressure Heart rate, but intramuscular injection is very weak antihypertensive effect, and also has antihypertensive effect on experimental renal hypertensive dogs and normal rabbits. Licorice decoction can make the blood pressure of Wuqi lose. Wuqi has no blocking effect on the ganglion, but it can resist the boosting reaction caused by epinephrine, norepinephrine and pituitrin. It has been reported that the effects of aqueous evodiamine extracts on cardiovascular function are generated through the excitation of α- and β-receptors.
The data show that the antihypertensive effect of E. rutaecarpa is produced by various active ingredients and various mechanisms. The antihypertensive effect of wuqi is related to the expansion of peripheral blood vessels; diphenhydramine may eliminate its antihypertensive effect and may therefore be related to histamine. But it has nothing to do with cholinergic nerves and their receptors. Dehydrovitaminone is one of the antihypertensive components, which has the effect of dilating blood vessels. While lowering blood pressure, it slows down the heart rate. The effect of reducing diastolic blood pressure is stronger than that of systolic blood pressure. Since indomethacin can partially, polyphosphate can completely The antihypertensive effect was cancelled, suggesting that antihypertensive effect is related to prostaglandin synthesis. Norfloxacin is also an antihypertensive component. Its antihypertensive effect also increases heart rate and reduces peripheral vascular resistance. This effect can be blocked by propranolol, indicating that its antihypertensive effect is related to the activation of β-receptors.
3. Studies on the effects of the digestive system have shown that the wolfberry bitterness contained in the wolfberry eucalyptus is a bitter taste and has a bitter stomachic effect. The volatile oil contained in it also has an aromatic stomachic effect. Ethanol extract of E. giganteae has anti-irrigation stress ulcer resistance in rat; water decoction also has anti-hydrochloric gastric ulcer and indomethacin plus alcoholic gastric ulcer, and it has water stress stress and pyloric pyloric ulcer. There is a tendency to inhibit formation.
Wuqi has a two-way effect on isolated small intestine activity, is excited at low concentrations, and inhibits spontaneous contractile activity at high concentrations. It can antagonize nicotine, physostigmine, acetylcholine, histamine, strontium chloride, phentolamine, and reserpine. Excitatory effect on isolated small intestine; also can inhibit the inhibitory effect of hexahydrocarbamate, atropine, and epinephrine on isolated small intestine, but can not antagonize diphenhydramine, papaverine, verapamil, and methotrexate on isolated rabbits Intestinal inhibition. It was suggested that the excitatory bowel effect of Evodia was not related to acetylcholine and M-cholinergic receptors, and its inhibitory effect may not be related to adrenergic nerves and α-receptors, but may be related to direct agonist β-receptors.
Erythromycin water decoction to mice oral (20g/kg), can significantly reduce the number of diarrhea-induced large intestine irritation diarrhea; the number of small intestinal irritation diarrhea caused by castor oil also tend to reduce. Wuqi slowed the gastrointestinal propulsive movement of normal mice, and also antagonized morphine or atropine's inhibition of gastrointestinal motility in mice, suggesting that the two-way effect of Wuqi on the intestine is beneficial to regulating the intestinal function of the body. Diarrhea caused by gastrointestinal disorders and indigestion diarrhea are also effective. Evodia can excite the bowel, and its cGMP may be involved in intestinal activity. Wu Hao excited the role of intestinal activity may be through cholinergic, histamine-like, anti-adrenergic-like effects or through either or through one of them.
4. Effects on uterine smooth muscle Wu Qizhong's sympathomimetic component has a relaxing uterus effect on hydroxyforint. Excluding the sympathomimetic component of the residual solution excitates the rat uterus and can counteract the relaxing effect of hydroxyfuric acid. Its excitatory uterus contains dehydroepiandronate, rutacarpine and rutinamine. Dehydro-evodiamine may be a serotonin receptor agonist, and its excitatory uterine effect can be blocked by dimethyl ergometrine and cannot be blocked by atropine.
5. Other effects Wujing decoction has a strong inhibitory effect on Vibrio cholerae; against Trichophyton mongolicus, Trichophyton concentricus, Brassica chinensis, Oxytobacter edulis, rust-colored spores 2. The fungal strains such as bacteria, wool-like spores, gypsophila spores, epidermophytes of the inguinal gland, and Nocardia star nostrils have different degrees of inhibition. Evodia water extract and 50% methanol extract have anti-caries effect. Erigeron has antiviral effects on mice infected with Columbia SK strain virus. In vitro experiments, Wuqi decoction and alcohol, ethyl ether extracts in vitro can kill swine fever, ticks and leeches.
Wuqi decoction has a diuretic effect on rabbits; healthy people also have a diuretic effect. The diuretic ingredients are evodiamine and ruthenium.
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