Application of residual oxygen meter in extending shelf life of drugs

Source: Shanghai Zhonglin Electromechanical Equipment Co., Ltd.

The quality of pharmaceuticals has always been the focus of Chinese consumers. Like food, medicines are products that are directly related to the health and safety of consumers. Medicines are special products used to prevent and treat diseases. The purpose is to regulate human physiology and treat diseases. Compared with food, due to the more professional medicines, the transparency and public participation in manufacturing are relatively low.

How to better ensure the quality of medicines and ensure the shelf life of medicines. Oxygen is the main factor affecting the majority of drug retention period. It has been found that by controlling the proportion of gas in the drug bottle, it can effectively extend the product warranty period or improve the amount of preservation to prevent oxidation. Shanghai Zhonglin Electromechanical Equipment Co., Ltd. launched oxygen and carbon dioxide packaging residual oxygen meter for the application of pharmaceutical packaging, mainly for small headspace, pharmaceutical packaging and other application fields. The instrument provides an efficient and accurate method to help manufacturers determine the suitability of the proportion of oxygen and carbon dioxide in the package to ensure shelf life goals. There are a variety of Zhonglin residual oxygen meter series, such as Oxybaby6.0, Mapy4.0, PA7.0, etc., which can be flexibly applied to production lines, warehouses, laboratories, etc., quickly and accurately to the gas component content and The proportion is evaluated to guide production and ensure shelf life of the product.

Oxygen and carbon dioxide are the sink points for the comprehensive detection of residual oxygen. Oxygen not only does not have a certain smashing effect on the medical status of drugs, but oxygen will cause oxidation of the outside of the drug, and the same taste will occur, resulting in the production of non-toxic substances. At the same time, oxygen is also the condition for most bacteria to proliferate. However, when the oxygen content is below x% and the carbon dioxide content is above Y%, the food and bacteria are in a state of stagnation, which can effectively extend the warranty period of the drug. Many drugs, such as low-priced iron salts, iodides, nitrites, and organic drugs containing unsaturated carbon chains, can be slowly oxidized by oxygen outside the atmosphere, causing discoloration, odor, decomposition, and variable effects. None of them may also cause toxicity, such as yellowing or white spots in large infusions.

Residual oxygen analysis can make it easier, accurate and fast to control the changes of gas composition inside the drug packaging, and become an important data support for analyzing drug quality, shelf life validity, and packaging design rationality. It is essential to strengthen product quality control. The means of detection, while the practical and reliable equipment is the basis for quality control and quality assurance.

At present, there are many kinds of residual oxygen meters in the market. There are many instruments that claim to be able to detect and analyze residual oxygen such as water injection, powder injection, large infusion bag and oral liquid. How to choose the appropriate residual oxygen analyzer?

The summary of Shanghai Zhonglin Xiaobian mainly needs to consider the following major factors: 1. What is the volume of the air at the top of the product? 2), sensor type 3 of residual oxygen meter, system response time. 4, other elements: like the characteristics of easy to carry.

In addition to pharmaceutical applications, Shanghai Zhonglin Residual Oxygen Meter can also be used in cheese, meat, poultry, seafood, cooked food, pasta, baked goods, fresh produce, carbonated beverages, coffee and other packaged food products.

With the implementation of the new GMP policy in China, higher requirements are put forward for the quality of Chinese medicines, and the research and development, production and quality management of pharmaceuticals are more strict and standardized. Only when the drugs meet the requirements and do not meet the requirements, must ensure the safety, effectiveness, uniformity and stability of the drugs to ensure the quality of medical care.