effect
1. Chuanxiong - Medicinal Herbal Medicine
The role of the central nervous system Chuanxiong has a clear sedative effect. When a small amount of Chuanxiong volatile oil has an inhibitory effect on the activity of the brain, it has an excitatory effect on the cerebral respiration center, the vasomotor center, and the spinal reflex center. Chuanxiong decoction to big, mice ig can inhibit their spontaneous activities, so that pentobarbital sodium caused by mice prolonged sleep time, and can combat the excitatory effect of caffeine (20mg/kg). However, it does not protect against pentylenetetrazole induced seizures in rats. The use of Chuanxiong decoction 25-50g/kg gavage, can inhibit the spontaneous activity of rats, the sedation of mice is more obvious than in rats; it can also prolong the sleep time of pentobarbital, but can not antagonize the excitement of caffeine Also, it does not prevent convulsions or lethal effects of pentamethasine tetrazole and cocaine. The volatile oil produced by Rhizoma Chuanxiong in Japan has an inhibitory effect on animal brain activity, but it has excitatory effects on the vasomotor center, respiratory center, and spinal cord reflex of the efferent brain. When the dose is increased, they all become inhibitory.
2. Effects on the Cardiovascular System 2.1 Effects on the Heart Chuanxiong Decoction increases the amplitude of contraction and the heart rate of isolated èŸ¾èœ and frog hearts at concentrations of 1O-5-10-4. According to the Englmann's test, Chuanxiong 20 or 30g/kgig also increased the amplitude of the frog heart and slowed the heart rate; with 40g/kgig, the heart of the frog could be arrested. Chuanxiongzin iv also has a strong heart effect on anesthetized dogs, accompanied by a rapid heart rate. To the heart of the vagus nerve, there is still a clear response to tetramethylpyrazine. Vertebral artery injection of a larger dose of tetramethylpyrazine, its cardiovascular effect is not obvious. Pre-administration of propranolol or reserpine can completely eliminate the effect of tetramethylpyrazine on the heart, so the effect of tetramethylpyrazine on the heart may be caused by the sympathetic nerve indirectly excited heart B receptor. Anesthetized dogs were intravenously infused with tetramethylpyrazine at 1, 2, and 4 mg/(kg.min) for 10 consecutive minutes. The animals showed an increase in heart rate, increased myocardial contractility, and vasodilation. These effects increase with the dose of mm). For 10 consecutive minutes, the animal has an increased heart rate, increased myocardial contractility, and dilated blood vessels. These effects increase with increasing doses. Infusion of lmg/(kg, minutes), heart rate, LVP and dp/dtmax increased, 2mg/(kg.min), heart rate, LVP, dp/dtmax and coronary blood flow increased significantly. When the dose was increased to 4 mg/(kg.min.), in addition to the above indicators increased significantly, there were LVEDP, CI, increased myocardial oxygen consumption and cerebral blood flow, and decreased coronary artery and cerebrovascular resistance and total peripheral resistance. The infusion of tetramethylpyrazine 4 mg/(kg.min) and 1 iv 20 mg/kg for awake high blood pressure dogs can also cause heart rate acceleration. Propranolol (ivl-2mg/kg) can counter these effects of ligustrazine on anesthetized and awake dogs, while reserpine does not completely counter the effects of ligustrazine. It has been reported that tetramethylpyrazine exerts a dose-dependent inhibition of myocardial contraction and increases arterial flow in isolated guinea pig perfused hearts. After Iv ligustrazine 10mg/kg, myocardial oxygen consumption, oxygen uptake and CBF were significantly increased within 1-5 minutes. Iv Ligustrazine 5mg/kg, 5 minutes, CBF increased 14 ± 15ml / min, so that every 100g of myocardial oxygen consumption increased by 1.0 ± 0.7ml / min, both significant. For anesthetic open-chest dogs, iv tetramethylpyrazine 10mg/kg can reduce blood pressure, external resistance and left ventricular work, increase LVSP, LVdp/dtmax, heart rate and myocardial oxygen consumption. Ligustrazine iv rabbits can protect ischemic myocardium from reperfusion injury, and its effects may be related to promoting blood circulation, increasing coronary blood flow, decreasing myocardial oxygen consumption and improving myocardial metabolism. Chuanxiong 150mg/kg was given to rabbits ig, 15 minutes later, iv pituitary pituitrin (Pit) 1.5 units/kg (30s finished), ivPit generally produces acute myocardial ischemia, electrocardiogram showed T-wave peak Significantly higher. The T-wave increase of the medication group was significantly lower than that of the control group, and there was a very significant anti-Pit-induced acute myocardial ischemia and hypoxia.
3. Effects on Smooth Muscle The 10% aqueous solution of Chuanxiong extract can excrete the uterus from pregnant rabbits in a trace amount, stimulate the pregnancy uterus, increase the tension, increase the contraction, and eventually become contracture. In large amounts, the uterine numbness and contraction stop. Chuanxiong extract continuous injection of pregnant rats and rabbits, the fetus necrosis results in the uterus, but does not fall, it is inferred that fetal necrosis may be due to animal uterus caused by the role of Chuanxiong contracture and affect fetal nutrition. Chuanxiong extract can inhibit a small amount of isolated rabbits or guinea pig small intestine, a large number can make the contraction of the small intestine completely stop. The ferulic acid and the neutral component (?-Lactone) contained in Chuanxiong have anticonvulsant effects on smooth muscle. Chuanxiong alkaloids, ferulic acid and Chuanxiong lactone have antispasmodic effect, while ligustilide is the main component of antispasmodic. Given guinea pig ip 0.14ml/kg ligustilide can relieve histamine and acetylcholine induced asthmatic effects, its effect is about 50mg/kg aminophylline similar. Iv Ligustilide also significantly relieves tracheal smooth muscle contractions caused by acetylcholine, histamine and barium chloride. Tetramethylpyrazine can also inhibit pulmonary vasoconstriction caused by hypoxia and also inhibit vasoconstriction caused by epinephrine or strontium chloride. The mechanism of tetramethylpyrazine from isolated tissues and cells showed that the relaxation effect of tetramethylpyrazine on aortic smooth muscle was very similar to that of asynchronous arrest, suggesting that tetramethylpyrazine may be a novel calcium antagonist. Chuanxiong ig300mg/kg mice, significant analgesic effect, compared with the control P <0.001.
4. In vitro experiments such as antibacterial effects of Chuanxiong have inhibitory effects on the large intestine, dysentery (Songne's), Deformation, Pyococcus, typhoid fever, paratyphoid bacillus, and Vibrio cholerae. Chuanxiong flooding (1:3) also inhibits certain pathogenic dermatophytes in vitro.
5. Anti-radiation effect Chuanxiong decoction has certain curative effect on experimental treatment of animal radiation sickness. Chuanxiong water-soluble crude preparations have protective effects on radiation exposure and nitrogen mustard injury in rats, mice and dogs. The anti-radiation effect of Chuanxiong on rats is better than that of mice, ip has better effect than im, and im administration has better effect than ig.
6. Other effects Ligustrazine can increase renal blood flow in anesthetized rabbits and can diurease. Ligustrazine can inhibit DNA synthesis, suggesting that it can inhibit protein and antibody production. Chuanxiong has some anti-vitamin E deficiency, which protects chicks from nutritional encephalopathy caused by vitamin E deficiency. Sodium ferulate can reduce the lipid peroxidation caused by H2O2 and O2, and has the effect of anti-OH and malondialdehyde (MDA) hemolysis. Sodium ferulate can significantly reduce complement hemolysis and inhibit the binding of complement 3b (C36) to the erythrocyte membrane. Ligustrazine has an inhibitory effect on pulmonary fibrosis in mice prepared by intratracheal administration of Pingyangmycin.
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