Multi-chamber infusion soft bags are currently classified into two main types in the large-scale infusion industry: liquid-liquid multi-chamber bags and powder-liquid multi-chamber bags. These products combine different infusion drugs within a single package, with separate chambers created through virtual welding. During production, storage, and transportation, these drugs remain isolated until clinical use, when external force is applied to open the virtual welds. Once mixed, the contents of the multi-chamber bag are typically unstable and cannot be stored for long periods. Therefore, they must be prepared just before administration, making the quality of the product critical.
This paper focuses on two key quality factors: the performance of the virtual welding and the barrier properties of multi-chamber infusion soft bags. The strength of the virtual weld is essential for ensuring both safe handling during storage and transportation, as well as ease of use in clinical settings. If the weld is too strong, it may be difficult to open; if it's too weak, it might fail during transit. Controlling this balance is a major concern for manufacturers.
To evaluate the heat-seal strength, Labthink’s HST-H3 heat seal tester and XLW (PC) intelligent electronic tensile tester are commonly used. When testing finished products, samples are cut directly from the weld area, and the “heat seal strength†test is selected on the XLW (PC). Additionally, manufacturers often conduct studies on the three key parameters—temperature, time, and pressure—to achieve optimal sealing. This process helps ensure that the welding meets both safety and usability standards.
Barrier performance is another crucial factor affecting the quality of multi-chamber bags. Whether it's a liquid-liquid or powder-liquid type, these bags require effective barriers against oxygen and moisture. To enhance protection, an inner packaging layer is often used. During production, nitrogen displacement packaging machines are employed to replace air inside the bags. As a result, barrier property tests typically include measurements of oxygen permeability, nitrogen permeability, and water vapor transmission rate. Labthink’s VAC-V series of differential pressure gas permeameters are designed for such comprehensive testing.
The application of multi-chamber bags represents a significant advancement in infusion soft bag technology. As part of strict pharmaceutical packaging requirements, these products must meet various quality standards, including tensile strength, elongation, heat-seal strength, puncture resistance, and sealing performance. Labthink has long been a trusted provider of testing instruments and services for the global pharmaceutical industry. We are committed to offering high-quality solutions to help companies maintain product integrity and compliance. For more information or to discuss potential collaborations, please contact Guo Sijia at gz@labthink.com.
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