Release date: 2007-10-25
Research: New findings suggest that intragastric fat may transform vitamin C from a cancer-preventing agent into a potential cancer promoter. According to a study by Combet et al. from the University of Glasgow, UK, while vitamin C is generally known for its anti-cancer properties, the presence of fat in the stomach could reverse this effect. The proximal stomach, which is particularly vulnerable to cancer, was the focus of their investigation. The researchers examined how fat and vitamin C interact with nitrite, a substance found in saliva and certain preserved foods. In acidic environments like the stomach, nitrite can be converted into harmful nitrosamines—known carcinogens. However, vitamin C typically prevents this by converting nitrite into nitric oxide, which blocks the formation of nitrosamines.
In laboratory experiments simulating human gastric conditions, the team observed that in the absence of fat, vitamin C significantly reduced the formation of various nitrosamines. For instance, increasing vitamin C levels decreased N-nitrosodimethylamine by five times and N-nitrosomorpholine by over 1,000 times. It even completely inhibited the formation of N-nitrosodiethylamine and N-nitrosopiperidine. But when 10% fat was introduced, the results changed dramatically. With vitamin C present, the formation of these harmful compounds increased by 8, 60, and 140 times, respectively, compared to when no vitamin C was added.
The researchers concluded that the presence of fat alters the role of vitamin C, shifting it from an inhibitor to a promoter of nitrosamine formation. They proposed that vitamin C enhances the production of nitric oxide in the water phase, and in the presence of fat, this nitric oxide reacts with oxygen, leading to the regeneration of nitrosylated compounds. These findings highlight the complex interactions between dietary components and their impact on health, suggesting that the benefits of vitamin C may depend on the overall composition of the meal consumed. ——Midi Medical Network
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