Alzheimer's disease, a neurodegenerative disorder characterized by cognitive decline. It is estimated that there are more than 35 million patients worldwide. China is a high-risk area of ​​Alzheimer's disease, and currently has the highest number of patients in the world. On the 11th, Professor Zhang Baorong, professor of the Department of Medicine of Zhejiang University, director of the Department of Neurology of the Second Affiliated Hospital of Zhejiang University, and member of the Chinese Alzheimer's Disease Association (ADC), announced the latest scientific and technological research results - found a kind of "IL-33" New protein, it is possible to reverse Alzheimer's disease.
At the end of 2012, Zhang Baorong led the research team of the Second Hospital of Zhejiang University, joined the research team of Prof. Ye Yuru of the Hong Kong University of Science and Technology, and Professor Liu Fuyou of the University of Glasgow, UK, to undertake a national key basic research development plan with the goal of pre-Alzheimer's disease. There is some gain in prevention. The "IL-33" protein found by the research group is present in various types of cells in the body, and it is particularly abundant in the central nervous system (brain and spinal cord).
The experts conducted a continuous observation of 35 adults for 3 years, of which 17 were healthy and 18 were mild cognitive impairment. Experts found that the serum "IL-33" protein was significantly reduced in patients with mild cognitive impairment compared with normal subjects. The team found that when there were too many Aβ plaque deposits in the brain, nerve fiber tangles were formed. "Plain" and "tangling" accumulate over time, leading to blockage of connections between nerve cells, eventually neuronal cell death, and loss of brain tissue function.
For normal people, the Aβ plaque is not terrible. Even if it is produced every day, it will not accumulate because of the “silver scavenger†of “IL-33â€.
The research team experimented with mice and installed a grid with weak current around the field where the mice live. Normal mice will realize the danger after touching the net, and they will no longer be close, but they have cognitive impairment. The mice will continue to touch the net. After injecting "IL-33" protein into mice with cognitive impairment for a week, and then returning it to this "dangerous" interactive place, the researchers were surprised to find that the mouse became smarter, as long as the net hit the electricity Then you will not make the same mistake again. It was also found through anatomy that the plaques in the heads of these mice were also significantly reduced. At the same time, it has been found by brain waves that sick mice have the same hallucinations as Alzheimer's disease, but they do not have hallucinations after being injected with "IL-33".
It is generally accepted in the medical community that if the patient is still in the preclinical or mild cognitive impairment period, early treatment can delay or prevent the progression of the disease. Unfortunately, most patients with Alzheimer's disease are often in the advanced stage when they are diagnosed. At that time, the nerve cells are necrotic and there is no possibility of reversal.
"This discovery has enabled the scientific community to have a better understanding of the cognitive barriers that are both complex and multi-cause, and to provide a new way to develop drugs for the treatment of this condition." Zhang Baorong said that these tests are significant. This indicates that the symptoms of Alzheimer's disease can be reversed.
Zhang Baorong said that if the clinical trial is successful, it is expected that 20% to 30% of patients with mild cognitive impairment or mild Alzheimer's disease will recover. Although the results of this study will continue to be teratogenic and toxic animal trials, at least three to five years of clinical trials from clinical applications, it has undoubtedly opened a window to treat Alzheimer's disease.
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