Release date: 2016-06-29
In the absence of traditional methods such as imaging and alpha-fetoprotein detection, detection of circulating non-coding single-stranded ribonucleic acid (microRNA) in serum can provide early warning and monitor the occurrence of liver cancer. This is a research group led by Academician Wang Hongyang from the Eastern Hepatobiliary Surgery Hospital of the Second Military Medical University, and an important research paper published in the internationally renowned academic journal Cancer Express. This method of detection is very simple and the cost is relatively low. Only the fingertip blood collection is required, and the test result can be obtained within 3 hours.
According to statistics, the 5-year survival rate after liver cancer resection is 30% to 50%, and the 5-year survival rate after microscopic liver cancer resection can be as high as 90%, and small liver cancer is about 75%. Therefore, early diagnosis and selection of appropriate means of treatment are of great significance to the prognosis of patients.
Dr. Li Liang and other researchers conducted a large-scale multi-center retrospective study under the guidance of Wang Hongyang. From April 2007 to March 2014, a total of 9287 chronic hepatitis B patients from 7 Chinese medical centers were followed up. These patients performed a quantitative physical examination of ultrasound and alpha-fetoprotein approximately every six months to monitor the occurrence of hepatocellular carcinoma. By retrospectively testing serum samples from patients with liver cancer before clinical diagnosis, the researchers found that one of them was specifically expressed by a microRNA molecular component of approximately 22 nucleotides in length encoded by an endogenous gene. Researchers have found that this group of markers can detect hepatocellular carcinoma earlier than traditional methods, and may even issue an early warning 12 months before clinical diagnosis.
Li Liang said that the microRNA combination is suitable for preclinical screening of high-risk populations of liver cancer, including chronic hepatitis, cirrhosis and hepatitis B virus infections older than 35 years old. At present, the relevant research plan has passed the ethical review of the Eastern Hepatobiliary Surgery Hospital. Researchers are paying close attention to the large-scale verification of the results of microRNA application for early warning of liver cancer, hoping to be pushed to the clinic as soon as possible.
Source: Health News
Fluorine-Containing Phenylamine
Most of the Fluorine-Containing Phenylamine products are a light yellow oily liquid, relatively high density, insoluble in water. Most of them are used in the manufacturing of pesticides and dye intermediates, small part of them can be used as an analytical reagent. The steam or smoke of fluorine-containing phenylamine series is irritated to eyes, mucous membranes and upper respiratory. Vapor and air can form explosive mixtures, in case of fire, high-heat combustion caused the explosion. And oxidant may react. Decomposition by high fever and emit toxic gases. In case of high fever, increased pressure within containers, cracking and the risk of explosion. Protective measures must be done carefully during product storage. Once the fire occurred, it must be immediately evacuated from air leakage,personnel to a safe area, prohibit access to the contaminated area. Recommended emergency personnel wearing self-contained breathing apparatus and wear chemical protective clothing. In the ambulance personnel to ensure proper safety measures, immediately use foam, carbon dioxide, dry, sandy soil to put out a fire.
Containing Phenylamine,2-Bromo-4-Methoxy-Phenylamine,5-Fluoro-2-Iodoaniline
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