Release date: 2015-12-16
Scientists at the University of Bath in the United Kingdom have invented a "smart" medical color-changing burn wound dressing. This dressing changes color when it detects infection in the wound. Such a color-changing dressing will strongly improve the treatment of burn patients and can effectively counter the global problem of antibiotic resistance by reducing unnecessary antibiotic use. Because the immune system is still relatively fragile, children are prone to bacterial infections when they are burned. These infections can impede the healing of wounds in children, leading to prolonged treatment and an increased risk of leaving permanent scars. In severe cases, burn infections can even lead to fatal sepsis. Currently, rapid clinical diagnosis of burn infections is still very difficult. The existing method requires at least 48 hours and is based on the removal of the wound dressing. The removal of the wound dressing can cause great pain to the patient and may slow the wound healing of the patient and leave a permanent scar. Due to the delay caused by the detection technique, when a burnt child shows a possible infection symptom, the medical staff has to use antibiotics as a precaution before the infection is confirmed. However, the use of antibiotics in uninfected conditions can cause bacterial resistance. Currently, antibiotic resistance is recognized as one of the world's biggest health threats.
Scientists at the University of Bath have worked with the Therapeutic Foundation Children's Burn Research Center, Bristol Children's Hospital, and Brighton University to develop a prototype of the dressing. This dressing changes color as long as an infection occurs. This dressing will help doctors quickly diagnose infections and take appropriate treatments to avoid unnecessary use of antibiotics.
Project leader Toby Jenkins, associate professor of biophysical chemistry at the University of Bath, explained: "The secretion of toxins by pathogenic bacteria in the wound triggers the release of fluorescent dyes in the nanocapsules of our medical dressings, thus changing the color of the dressing." “Nano-capsules mimic skin cells, open only in the presence of pathogenic bacteria and release fluorescent dyes; other harmless bacteria in healthy skin have no effect.†“Using this dressing allows medical workers to remove dressings without having to remove them.†The infection can be diagnosed, which means that the diagnosis and treatment of the condition will be more rapid and effective.†The team has been awarded nearly £1 million in research funding from the Medical Research Council through the Biomedical Catalyst Funding Channel to test the dressing. The ability of the prototype to respond to samples taken from wounds in burn patients.
As a national alumnus of the National University of Singapore (NUS), Dr. Thet Naing Tun, a senior research assistant who has been working on this research at the University of Bath, said: "We designed and tested the performance of the dressing using a biofilm model in the laboratory. Thank you very much for medical research. The Council (MRC) has provided us with research funding, and we are now able to move the project to the next stage. Next we will improve the design and clinical performance of the dressing. We hope that the dressing will be clinically available in the next three to five years. Dr. Amber Young is the leader of the Children's Burns Research Center at the Bristol Children's Hospital Treatment Foundation.
She will provide Dr. Jenkins with wound gauze and blister fluids from burned children to test the performance of this new medical dressing in response to infection. “Children are particularly prone to serious infections, even very small burns,†she said. However, with current methods, medical staff cannot tell whether a rise in body temperature is due to a serious bacterial infection in a burn wound or simply because of a cold.†Using this dressing to quickly and accurately diagnose infections in burn wounds allows doctors to take appropriate treatments at the right time, which will bring evangelism to thousands of burnt children. Importantly, this It can also reduce the threat to human health caused by global antibiotic resistance."
Scientists at the University of Bath have worked with the Therapeutic Foundation Children's Burn Research Center, Bristol Children's Hospital, and Brighton University to develop a prototype of the dressing. This dressing changes color as long as an infection occurs. This dressing will help doctors quickly diagnose infections and take appropriate treatments to avoid unnecessary use of antibiotics.
Project leader Toby Jenkins, associate professor of biophysical chemistry at the University of Bath, explained: "The secretion of toxins by pathogenic bacteria in the wound triggers the release of fluorescent dyes in the nanocapsules of our medical dressings, thus changing the color of the dressing." “Nano-capsules mimic skin cells, open only in the presence of pathogenic bacteria and release fluorescent dyes; other harmless bacteria in healthy skin have no effect.†“Using this dressing allows medical workers to remove dressings without having to remove them.†The infection can be diagnosed, which means that the diagnosis and treatment of the condition will be more rapid and effective.†The team has been awarded nearly £1 million in research funding from the Medical Research Council through the Biomedical Catalyst Funding Channel to test the dressing. The ability of the prototype to respond to samples taken from wounds in burn patients.
As a national alumnus of the National University of Singapore (NUS), Dr. Thet Naing Tun, a senior research assistant who has been working on this research at the University of Bath, said: "We designed and tested the performance of the dressing using a biofilm model in the laboratory. Thank you very much for medical research. The Council (MRC) has provided us with research funding, and we are now able to move the project to the next stage. Next we will improve the design and clinical performance of the dressing. We hope that the dressing will be clinically available in the next three to five years. Dr. Amber Young is the leader of the Children's Burns Research Center at the Bristol Children's Hospital Treatment Foundation.
She will provide Dr. Jenkins with wound gauze and blister fluids from burned children to test the performance of this new medical dressing in response to infection. “Children are particularly prone to serious infections, even very small burns,†she said. However, with current methods, medical staff cannot tell whether a rise in body temperature is due to a serious bacterial infection in a burn wound or simply because of a cold.†Using this dressing to quickly and accurately diagnose infections in burn wounds allows doctors to take appropriate treatments at the right time, which will bring evangelism to thousands of burnt children. Importantly, this It can also reduce the threat to human health caused by global antibiotic resistance."
Source: Bio 360
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