Pharmaceutical toxicology
The median lethal dose of mice for an intraperitoneal injection was 29.0 ± 0.8g/kg for the Uncaria decoction, l44.2 ± 3.1mg/kg for total alkaloids, and 162.3mg/kg for rhynchophylline. Total alkaloids were 514.6 soil 29.1 mg/kg. In terms of subacute toxicity, rabbits were treated with uncaria decoction twice a day, each time at 5g/kg (2.5 times the amount of treatment), and they were taken for 10 days without symptoms of poisoning. Rhynchophylla 50mg/kg continuous administration for 14 days, does not cause pathological changes in the rat viscera; dose doubled, although the liver has mild inflammatory changes, the drug returned to normal after discontinuation; no effect on diet, weight and appearance behavior .
toxicity:
The LD50 of intraperitoneal injection of rhynchophylline and rhynchophylla total mice were 162.3 mg/kg and 144.2 mg/kg, respectively, and the activity was reduced when intoxicated, and the whole body was weak. The daily decoction of 10 g/kg was given to rabbits twice. 10 days, Rhynchophylline was administered to the rats at 50 mg/kg for 14 days. There were no changes in symptoms of toxicity and visceral pathology. Rhizoma Alkaloids were fed to the young rats at 50 mg/kg and 100 mg/kg, respectively. The low-dose group had no significant effect on growth, development, liver and kidney function, and hemogram. However, in the high-dose group, the heart, liver, and kidney of the lethal animals showed obvious pathological changes. Therefore, attention should be paid when taking a large dose or long-term use. Liver and kidney function tests.
The median lethal dose of the uncariatine decoction on mice injected intraperitoneally was 26.1±4.3 g/kg or 29.05±0.8 g/kg. Uncaria twig decoction was 35.2 ± 5.4g/kg. The median lethal doses of total alkaloid hydrochloride of Uncaria rhynchophylla in mice by gavage and intraperitoneal injection were 514.6±29.1 mg/kg and 144.2±3.1 mg/kg, respectively. The median lethal doses of quercetin to mice injected intraperitoneally and subcutaneously were 162.3 mg/kg and 165 mg/kg, respectively.
The rabbits were fed with a decoction of uncaria Houttui 5g/kg twice daily for 10 consecutive days without obvious symptoms of poisoning. Young rats were treated with 50 mg/kg total alkaloid hydrochloride (therapeutic dose) for 1 day and dissected after 14 days. No visceral pathological changes were observed. However, when the dose is doubled, mild inflammatory changes occur in the liver and recovery can be quickly achieved after drug withdrawal. Weaning rats were treated with total alkaloid hydrochloride 50-100 mg/kg, once daily for 2 months, and then observed for 1 month after discontinuation. Small doses (50 mg/kg) were given to animals for growth, development, and liver There was no significant effect on renal function and blood count. Pathological examination showed only mild renal nutritional disorders. Large doses (100 mg/kg) can kill animals. Death of the animal heart, liver and kidney have obvious lesions.
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