Pharmacological effects
Diuretic effect
Rhizoma Imperatae decoction and aqua impregnated, the diuretic effect of normal rabbits, administration 5-10 days, the most obvious effect of diuresis, about 20 days is not obvious. However, the dosage used, in particular, the amount of water in the animal is not known, and there is no control group, and further studies are needed. Some people think that the diuretic effect of Rhizoma Imperatae is related to its rich potassium salt.
Hemostatic effect
Rhizoma Imperatae Powder can significantly shorten rabbit recalcification time. However, Rhizoma Imperatae contains more calcium and may interfere with the experimental results. Rhizoma Imperatae powder is sprinkled on the bleeding femoral artery in dogs or rabbits and compressed for 1-2 minutes to stop bleeding. Clinical Rhizoma Imperatae treatment of nasal discharge.
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Treatment of acute nephritis better effect, can shorten the course of the disease. According to dozens of observations, urinary urination is usually significantly increased in the first 1 to 5 days after administration, and it can reach about 1500 to 3000 ml per day. As the edema gradually disappears, the hypertension and urine test changes gradually and normalizes. According to some cases, the disappearance of edema is about 4 to 5 days or about 1 week on average; the normal blood pressure is 5 to 20 days, with an average of 7 to 9 days; the average disappearance time of urinalysis varies from 11 to 26.4 days. For chronic nephritis also diuretic swelling and a certain degree of antihypertensive effect. However, ascites caused by liver disease and heart failure caused by edema, there is no diuretic swelling effect or role is not significant. Therefore, it was speculated that the role of Rhizoma Imperatae is mainly to alleviate glomerular vasospasm, so that the renal blood flow and renal filtration rate increased diuretic effect; while improving renal ischemia, reduced production of renin, so that blood pressure returned to normal. Therefore, the efficacy of acute nephritis is good, and the efficacy of chronic nephritis is poor, while it is not effective for hepatic and heart disease edema. No adverse reactions were observed except for slight dizziness or nausea during medication. Usage: Generally Rhizoma Imperatae (dry) half a catty, washed and chopped, decoction, daily 2 to 3 times sub-service. Even take 1 to 2 weeks or to recover. There are also compound prescriptions for the treatment of Dalat, Otter, Rehmannia or Ephedra. At the same time, taking medication should pay attention to bed rest, limit the intake of water and salt, and keep warm. If necessary, other drugs can be properly added to control complications and lesions.
Treatment of acute infectious hepatitis
Rhizoma Imperatae (dry product) 2 two, decoction, served twice daily. Treatment of 28 cases resulted in clinical cure (main symptoms and signs disappeared within 45 days, liver function returned to normal) in 21 cases, improved (clinical symptoms improved, the value of liver function decreased by more than half within 45 days, or fully recovered after 45 days) 7 example. After treatment, most of the main symptoms disappeared within 10 days. The hepatosplenomegaly disappeared in about 20 days. After 45 days, alanine aminotransferase was reduced to normal in 80% of patients, and the average jaundice index was normal in 20.15 days. No side effects.
Antibacterial effect
The Rhizoma Imperatae decoction has obvious inhibitory effect on the F.sclerotiorum and S. dysenteriae in vitro, but it has no effect on Shigella and Shigella dysenteriae.
Effects on Myocardial 86Rb Uptake
Intramuscular injection of Rhizoma Imperatae extract increased the myocardial uptake of 86Rb.
Pharmaceutical toxicology
The rabbits were decocted at 25g/kg, and the activity was suppressed after 36 hours. The movement was slow and the breathing increased, but it quickly recovered. Intravenous injection of 10-15g/kg, there will be increased breathing, exercise inhibition. Gradually recovered after 1 hour, the dose increased to 25 g/kg and died after 6 hours.
Other effects
The alfalfa contained in Rhizoma Imperatae inhibits the contraction and metabolism of skeletal muscle. In addition, there are sedation, antipyretic analgesia, fever, polydipsia, stomach vomiting, hyperactivity, cough, edema, and jaundice.
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