Release date: 2009-03-30
Recently, a groundbreaking study published in *Science* revealed that spinal cord electronic devices developed by U.S. researchers have shown promising results in helping rats with Parkinson’s disease become more active. This innovative technology could potentially offer a less invasive treatment option for patients suffering from this debilitating condition.
The research was led by Dr. Miguel Nicolelis from Duke University. The new device involves implanting two ultra-thin sensors into a small incision in the spine, allowing them to interact directly with the spinal cord. These sensors then deliver electrical pulses that stimulate the peripheral nerves responsible for transmitting signals between the brain and the body.
In healthy individuals, nerve cells fire at different rates, enabling smooth and coordinated movement. However, in Parkinson’s disease, these nerve cells become overactive and fire simultaneously, disrupting normal motor function. This leads to a decrease in dopamine production, a neurotransmitter essential for movement. Current treatments often rely on dopamine replacement drugs like levodopa, which can temporarily ease symptoms but do not provide a long-term solution.
In experiments with mice, the researchers tested the device alongside levodopa. They found that when used together, only two doses of the drug were needed to restore mobility, compared to five doses when the drug was used alone. Additionally, the device helped extend the effectiveness of levodopa over time, suggesting it could reduce the need for higher doses as the disease progresses.
Compared to existing brain implants, this spinal-based approach is less complex and easier to implement. The team plans to test the device on primates in the near future and aims to begin human trials by 2010.
Parkinson’s disease affects around 1.5 million people in the United States and is one of the most common neurodegenerative disorders among older adults. Symptoms include slow movement, tremors, stiffness, and difficulty with balance. Often referred to as the “third killer†and “chronic cancer†of the elderly, it ranks behind only cancer and cardiovascular diseases in terms of impact on public health.
Shanghai Medical Device Industry Association
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