Shangshan medicine is a way of obtaining medicines from traditional Chinese medicine, and today Chinese scientists are accelerating the study of new medicines for obtaining intractable diseases from the ocean.
The new drug for the treatment of Alzheimer's disease, “Ganlu oligosaccharide (GV-971)â€, which was developed by the Chinese Academy of Engineering academician Guan Huashi's research team, successfully completed Phase III clinical trials.
The results showed that this new marine oligosaccharide molecule derived from seaweed was expected to achieve the main efficacy index of cognitive function improvement, with statistical significance and clinical significance.
Experts said that the novel mode of action and unique multi-target action characteristics of this new drug have opened up a new path for Alzheimer's disease drug research and development, and are expected to lead the new wave of marine sugar drug research and development, promote Chinese medicine theory and marine innovative drug research and development. Deep integration has far-reaching significance for enhancing China's international status in the field of innovative drug research.
The early development of GV-971 originated from the marine drug research team of China Ocean University led by Guan Huashi, and further in-depth research and development was completed by the Shanghai Institute of Materia Medica and the Green Valley Pharmaceutical of the Chinese Academy of Sciences.
"The special structure and biological activity of marine natural products have special effects on the treatment of tumors and neurological diseases, and become a new hope for human treatment of incurable diseases." Guan Huashi, 79, said this year.
According to reports, humans have discovered 35,000 marine natural products, more than half of which are biologically active, far more biologically active than the natural products of plants and animals on land, and there are many unknown marine natural products, so the ocean can provide a large number of Drug lead compound.
“So far, only 13 new marine drugs have been listed in the world, and the potential of the marine biomedical industry is huge,†said Guan Huashi.
Among the 13 new marine drugs that have been listed, one of China's contributions is the sodium alginate diester developed by Guan Huashi in 1985. It is a polysaccharide sulfate drug extracted from natural seaweed for prevention and treatment of deficiency. Bloody heart, cerebrovascular disease.
Guanhua’s team is building a “blue drug storehouse†in Qingdao, and has initially established a marine biological resource bank and a marine drug-related information base. In the future, it will focus on the development of marine small molecule drugs, marine sugar drugs, marine Chinese medicine and marine life functions. Products.
In the development of “Blue Medicine Libraryâ€, the Chinese Ocean University Medical College led by Guan Huashi is engaged in basic research, Qingdao Marine Biomedical Research Institute is engaged in industrialization, clinical trials and marketing promotion are handed over to cooperative enterprises; Qingdao Marine Biomedical Research The hospital also established a “China Blue Medicine Library Development Fund†with a total scale of 5 billion yuan with Zhengda Pharmaceutical (Qingdao) Co., Ltd., which initially formed a complete chain of marine drug research and development.
A new marine medicine takes a long time from the acquisition of natural marine products to the market for drugs. GV-971 has spent 21 years, and the marine anticancer drug “Qubebutidine†has been going on for nearly 40 years. The team of Guan Huashi will use the big data and super-calculation technology to greatly accelerate the pace of research and development of new marine drugs.
Yang Jinbo, chief scientist of Qingdao Marine Biomedical Research Institute, introduced a three-dimensional structure database containing about 30,000 marine natural products, and initially constructed a database of all drug molecular targets published by the US Food and Drug Administration.
"We will rely on the super-computing resources of Qingdao, Jinan and Wuxi and the established database resources to compare the three-dimensional structure of marine products with the molecular target data of drugs, just like comparing 'key' and 'lock' And calculation." Yang Jinbo said.
Yang Jinbo said that in the past, drug screening was a blind test of trace marine natural products on drug molecular targets, and the application of supercomputer technology was big data calculation and matching. This technology will increase the accuracy of marine drug screening from less than 20% to more than 60%.
Guan Huashi told reporters that the research and development of marine new drugs under the guidance of TCM theory will be the advantage and key direction of the “blue drug storehouseâ€.
"In order to treat Alzheimer's disease, more than 130 drugs have been tested in 16 countries. The success of GV-971 is based on the theory of traditional Chinese medicine. The effect is multi-component, multi-target, The result of synergy. This drug not only acts on the hippocampus of the head, but also regulates the imbalance of the intestinal flora and remodels the immune homeostasis of the body, thereby reducing neuroinflammation in the brain and preventing the progression of Alzheimer's disease. The poem says.
The team of Guan Huashi is looking forward to the continuous innovation in the “Blue Medicine Libraryâ€. Three to four new marine medicines will enter clinical research in the next three to five years. Among them, BG136 for treating colon cancer and TGC161 for anti-HPV virus are expected to be the first to succeed. BG136 is developed from the extraction of natural products from Antarctic ice algae and is scheduled to be submitted for clinical research by the end of next year.
Qingdao is a city of marine technology in China. It gathers more than 30% of China's marine teaching and research institutions, 50% of sea-related researchers, 70% of sea-related experts and academicians, and has the “Jianlong†and “Science†numbers. "Xiangyanghong 01" and other Chinese marine "Keokuli", which will provide strong intellectual support and a steady stream of marine biological sample resources for the "Blue Medicine Library". (According to Xinhua News Agency reporters Zhao Xinbing, Xu Bing, Zhang Xudong)
China Daily chemical Suppliers
Here you can find the related products in Daily chemical, we are professional manufacturer of Daily chemical. We focused on international export product development, production and sales. We have improved quality control processes of Daily chemical to ensure each export qualified product.
If you want to know more about the products in Daily chemical, please click the Product details to view parameters, models, pictures, prices and Other information about Daily chemical.
Whatever you are a group or individual, we will do our best to provide you with accurate and comprehensive message about Daily chemical!
Hydrolyzed Keratin, Menthol, Daily Chemistry, Cosmetics Field
Xi'an Gawen Biotechnology Co., Ltd , https://www.ahualynbios.com