Original title: Virus variants found in cases of H7N9 infection in Guangdong
On the 19th, the Chinese Center for Disease Control and Prevention published the official website. In January this year, the Guangdong Provincial Center for Disease Control and Prevention conducted a gene sequencing analysis of the two cases of human isolated H7N9 virus isolates and found the location of the hemagglutinin linker peptides in the two viruses. Gene insertion mutations have occurred and the test results have been reviewed and confirmed by the National Influenza Center of the National Center for Disease Control and Prevention.
The National Center for Disease Control and Prevention organized expert judgments and communicated with relevant experts in the agricultural sector that the H7N9 virus had an insertional mutation in the location of the hemagglutinin linker peptide, suggesting that the virus had been mutated to avian highly pathogenic virus; According to the result of the virus sequence analysis, no mutation has occurred in the mutant virus that has increased human infectivity, virulence, and interpersonal transmission.
The relevant person in charge of the Guangdong Provincial Center for Disease Control and Prevention stated that from the analysis results, there is little impact on the prevention and control of human infection with H7N9, but it has a greater impact on the poultry breeding industry, transportation industry, sales and slaughter industries. Because there is currently no H7N9 poultry vaccine, the emergence of highly pathogenic changes in the virus may cause the birds to be affected. The responsible person also revealed that in recent days, Guangdong Province has found that the surrounding environment of the live poultry market has been polluted, and the positive rate of the H7N9 virus has increased. This is not a special case this year. It is similar to the monitoring results of the high incidence season of avian influenza in previous winter and spring seasons.
This year's tests and analysis also reminded us that there was also a history of bird exposure. In previous years, people were infected with H7N9, and often the chickens tested for exposure were not sick or dead; this year they found that people were infected, and the chickens they exposed were morbid and dead. . "However, because there are few cases of H7N9 virus variants, it is unclear how much of the virus variant is present in poultry. We will continue to strengthen monitoring," said the person in charge.
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In the province of H7N9, 79 deaths of experts warned against contact with live poultry
Xinhua News Agency, Beijing, February 15 (Reporter Lu Nuo) The reporter learned from the National Health and Family Planning Commission on the 15th that since the beginning of this year, a total of 16 provinces have reported cases of H7N9 bird flu. Among them, 192 cases were reported in January and 79 cases were fatal.
Winter and spring are high incidences of H7N9 and other respiratory infectious diseases. Shu Yuelong, deputy director of the China Center for Disease Control and Prevention and Director of the National Influenza Center, said that since the beginning of winter last year, due to climate and other factors, China's H7N9 epidemic has experienced an increase in the number of cases, a wide distribution area, a high degree of dissemination, the majority of cases Distributed in the Yangtze River Delta and the Pearl River Delta region. However, the overall characteristics of the epidemic have not changed. Exposure to infected poultry or exposure to live poultry markets is an important risk factor for human infection. The available evidence shows that the virus cannot yet cause continuous human-to-human transmission. Ni Daxin, deputy director of the China Center for Disease Control and Prevention Center, introduced that in some cities and regions such as Zhejiang, Jiangsu, Anhui, and Guangdong provinces, new cases have been significantly reduced or no new cases have emerged; the control of live poultry transportation to and from the country has been strengthened. Enhance livestock quarantine and preventive measures such as cleaning and killing, and actively promote the implementation of long-term measures such as prohibiting live poultry trade, promoting the transformation and upgrading of the poultry industry, and implementing the circulation and listing of chilled poultry products.
From the current situation, the overall mortality of H7N9 bird flu patients is about 40%. Chen Zhihai, chief physician of the Beijing Ditan Hospital Infection Center, said that existing antiviral drugs such as oral oseltamivir and intravenous infusion of palamivir can effectively inhibit the influenza virus. However, the sooner these drugs are used, the better the effect is, and the reason for the higher mortality rate of the patients is mainly the missed time for the best treatment. Therefore, patients with fever should seek treatment as soon as possible and use antiviral drugs as soon as possible.
Experts suggest that the public should avoid contact with live animals in their daily lives, not to contact sick and dead poultry, especially in areas where winter and spring seasons and epidemics occur. If contact is required, wash hands as soon as possible; in addition, efforts should be made to change the habits of purchasing and consuming live poultry, and to purchase chilled fresh poultry, chilled birds and their products with quarantine certificates. Raw poultry meat and eggs must be fully cooked and thoroughly cooked. After processing raw poultry meat and eggs, thoroughly wash hands; food processing should be done separately; if there are fever and respiratory symptoms, wear masks as soon as possible. Visit. (Source: Guangzhou Daily)
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