Release date: 2018-05-18
Recently, a research report published in the international magazine PNAS, scientists from Ohio University and Utrecht University identified a new type of swine virus, and these pig viruses can find a special By infecting human cells and other animal cells cultured in laboratories, this study suggests that attention should be paid to the potential threats to human health from this new type of swine virus.
In the article, the researchers deeply understand the potential spread of the virus, and the researchers also first clarified the propagation characteristics of the virus among different species. In 2012, researchers first identified the Porcine deltacoronavirus (PDCoV), a newly emerging porcine coronavirus in China, but it does not seem to induce disease, and the outbreak of swine dysentery in Ohio in 2014 During the first time, the researchers detected the virus, and the researchers subsequently detected the virus in several countries. Young infected pigs showed symptoms of acute diarrhea and vomiting, and the disease was fatal, but There are still no cases recorded so far, but scientists are very worried about this possibility.
Researcher Dr. Linda Saif said that before the virus was discovered in pigs (the porcine dysentery epidemic in Ohio), the PDCoV virus is present in a variety of birds. We are very concerned about the emergence of new coronaviruses and are very concerned about these new types. The potential harm of coronavirus to humans and other animals; the researchers in this study identified novel porcine viruses that may cause concern to veterinarians and public health experts because they are very similar to SARS and MERS viruses.
Whether such a novel virus can cross from one species to another depends to a large extent on its ability to bind to cellular receptors in animals or humans. The receptor is like a door lock. If the virus can be unlocked, then Can enter cells and potentially infect the host; in this study, the researchers conducted an in-depth study of a specific cellular receptor called aminopeptidase N, the researcher Kenney said, we found from other studies of coronavirus These cellular receptors can be used and are present in the respiratory and digestive tracts of many different animals. Today we know that this new virus can enter cells of other different species (including humans).
More importantly, researchers now find that these viruses can infect human cells and other species of cells cultured in the laboratory. This virus not only binds to receptors in pig cells, but also binds to human cells, cats and chickens. Receptors on cells, from this point of view, can this new virus replicate in cells and cause disease in animals and humans? This may have caused many researchers to worry.
In the next step, the researchers hope that through more in-depth research to understand whether the virus will replicate in human cells and cause infection, and researchers hope to find special antibodies in human blood as evidence that the pig virus has infected humans. Finally, the researcher Saif said that we are now very sure that the PDCoV virus can bind to and enter the cells of humans and birds. Next we will continue to study the host cells' susceptibility to this new type of swine virus infection, and clarify Whether the virus can be transmitted to chickens or humans through sick pigs.
Source: Bio Valley
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