Chinese professors find new ways to eliminate addiction

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Chinese professors find new ways to eliminate addiction

February 13, 2017 Source: Beijing Youth Daily

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The view that “pathological addiction memory is difficult to eliminate once it is formed” is now broken by the research results of Chinese experts, which the international community calls “a landmark step toward treating smoking addiction and other substance addictions”.

This year's latest issue of JAMA Psychiatry ("American Medical Association Journal Psychiatry") published Professor Lu Lin of Peking University's Sixth Hospital (Peking University IDG/McGovern Brain Institute and Peking University-Tsinghua University Life Science Joint Center) PI) The research group entitled "Applying the effect of propranolol-specific inhibition of nicotine-related memory on the psychological craving of nicotine". The study successfully transformed the results from animal research to clinical trials, eliminating the addictive memory of nicotine dependent patients and reducing psychological cravings. This groundbreaking research result brings the gospel to people who are difficult to quit, and it is expected to overcome the medical and social problems of long-term effective treatment of pathological memory-related mental and psychological problems such as nicotine dependence.

The study received international attention. The magazine published a review article at the same time, arguing that the series of research findings of Lu Lin's research group have changed the traditional view that pathological addiction memory is difficult to eliminate once it is formed, and found a treatment to eliminate the core pathological mechanism of substance addiction. A landmark step in addiction and other substance addiction.

According to Professor Lu Lin, the essence of tobacco addiction and dependence is nicotine dependence, which is a chronic high recurrent disease. Nicotine causes plasticity changes in the brain's neural pathways, forming a strong and persistent nicotine addiction memory, and the nicotine dependents continue to have a desire to smoke, a desire that weakens or even destroys the determination to quit. Therefore, eliminating the pathological addictive memory of nicotine dependent patients and reducing psychological craving are the key to the success of clinical smoking cessation.

The study successfully transformed the results from animal research to clinical trials. First, it was found in the animal nicotine addiction memory model that low-dose nicotine was used as an unconditional stimulus to evoke addiction memory, and the naphthalene was given in the re-consolidation time window. Lol can effectively eliminate all nicotine addiction memories of animals. Further research in smoking addictions found that after unconditional stimulation (referring to nicotine entering the body after smoking), oral propranolol can eliminate smoking-related memory and reduce multiple smoking after re-consolidation time window. Relevant clues induce psychological cravings.

Professor Lu Lin said that the 2013 World Health Organization's Global Tobacco Epidemic Report pointed out that tobacco use is the leading cause of preventable deaths worldwide, causing nearly 6 million deaths worldwide and causing hundreds of billions of dollars in economic losses. If current trends continue, by 2030, the world’s annual deaths from tobacco will exceed 8 million. According to the "2015 China Adult Tobacco Survey Report" issued by the China Center for Disease Control and Prevention, the smoking rate of Chinese people aged 15 and over is 27.7%, and the male smoking rate is 52.1%. The total number of smokers increased by 15 million in the five years from 2010 to 2015, reaching 316 million.

It is reported that this research is an important achievement of the Lulin research team on the basis of the previous series of research. Lu Lin's group published papers in Science and Nature Communications in 2012 and 2015, respectively, and proposed conditional clue memory arousal and unconditional clue memory arousal - extinction psychology Paradigm, found that the memory manipulation paradigm can eliminate the addictive memory of addicted animals and addicts, reducing their psychological desire for addictive drugs and the risk of relapse. These research results have also been repeatedly verified by international peers in other addictive animal models and addictive populations.

Associate Professor Xue Yanxue of Peking University China Institute of Drug Dependence and Dr. Deng Jiahui of Peking University Sixth Hospital are the first authors of the paper. Lu Lin is the author of the communication. The research was supported by the National Natural Science Foundation of China and the National Key Basic Research and Development Program ("973") of the Ministry of Science and Technology. Wen / Fu Donghong (Peking University School of Medicine)

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