Release date: 2010-01-04
Cancer progression is often thought of as a process in which primary tumors are constantly metastasizing, and a recent study by US scientists found that circulating tumor cells, cancer cells that have spread out of the primary tumor and spread to other parts of the body, can return to their original state. The tumor continues to develop, thereby enhancing tumor growth. This process is called "self-seeding." Researchers say the findings contribute to the development of new targeted cancer treatments. Related research results were published in the December 25 issue of Cell.
Jin Miyong, a researcher at the Department of Cancer Biology and Genetics at the Sloan-Kettering Cancer Center in New York, said that their research not only reveals the phenomenon of self-injection and its mechanism, but also reveals Its role in the development of tumors.
Experiments conducted by the researchers in mice have shown that self-excited injection involves two different functions: one is that the tumor attracts its own circulating products, that is, the ability to circulate tumor cells; the other is that the circulating tumor cells respond to tumor attraction. The ability to infiltrate into a tumor. The researchers identified four genes responsible for performing these functions: IL-6, IL-8, FSCN1, and MMP1. Among them, IL-6 and IL-8 are responsible for attracting the most aggressive part of the circulating tumor cell population, while FSCN1 and MMP1 are responsible for the regulation of re-infiltration of circulating tumor cells.
Studies have shown that circulating breast cancer cells have similar gene expression patterns as described above, and breast cancer cells can spread to the lungs, bones, and brain, thereby increasing the chance of tumor metastasis to these organs. In addition to breast cancer, self-injection can also occur in other types of cancer cells, including colon cancer and melanoma.
Researchers believe this finding is important. Dr. Joan Masageu, chairman of the Department of Cancer Biology and Genetics at the Sloan-Kettering Cancer Center, said the findings provide a good opportunity to develop new targeted therapies that are self-motivated through intervention. The injection process slows down or even prevents tumor progression.
Dr. Larry Norton, deputy director of the Center for Breast Cancer, pointed out that the discovery of self-injection provides a new perspective for clinical observation in cancer treatment. Doctors know that the size of the tumor is related to the quality of the prognosis. It is generally believed that large tumors release more cancer cells with metastatic potential, resulting in poor prognosis. But in fact this association may be caused by self-induced injection of aggressive cancer cells, and a similar mechanism promotes the growth of local tumors and the metastasis of distant tumors. Meditech Medical Network
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