Harbin Medical University reveals the mystery of cerebral ischemia-reperfusion injury

Harbin Medical University has made a significant breakthrough in understanding cerebral ischemia-reperfusion injury. According to research led by Professor Yan Sihua from the Department of Anesthesiology at the Fourth Affiliated Hospital, certain intravenous anesthetics can effectively inhibit neuronal apoptosis following brain ischemia and reperfusion. The study, supported by the National Natural Science Foundation of China, uncovered the mechanisms behind this protective effect, which involves the regulation of apoptosis-related factors. This research was recognized with the First Prize of the Heilongjiang Provincial Medical and Health Science and Technology Progress Award in 2006. Professor Qi Sihua highlighted that conditions such as shock, cardiac failure, cerebral vascular stenosis, or hypotension can lead to cerebral ischemia and hypoxia. Reperfusion after these events often causes additional damage, resulting in cognitive impairments, motor difficulties, memory loss, and even vegetative states. As a result, preoperative brain protection has become a critical focus for anesthesiologists. Clinical studies have shown that various anesthetics offer some degree of protection to the heart and brain, but the exact mechanisms remain unclear. Through animal experiments, it was found that apoptosis plays a key role in neuronal death after cerebral ischemia-reperfusion. Professor Yan Sihua discovered that ketamine, thiopental, midazolam, and propofol can significantly reduce neuronal apoptosis by interfering with the release and expression of apoptosis-regulating proteins. The study also revealed that different anesthetics have distinct protective mechanisms, and their effects are dose- and time-dependent. Experts believe this research not only clarifies the causes of cerebral ischemia-reperfusion injury but also provides a solid foundation for the safe and effective use of intravenous anesthetics, potentially improving outcomes for patients with cerebrovascular diseases and reducing postoperative complications. — Midi Medical Network

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