Model NO.: 147127-20-6
CAS: 147127-20-6
Package: 25kg Drum
Trademark: YCGC
Transport Package: Foil Bag
Specification: 10g
Origin: China
HS Code: 12345677
Model NO.: 147127-20-6
CAS: 147127-20-6
Package: 25kg Drum
Trademark: YCGC
Transport Package: Foil Bag
Specification: 10g
Origin: China
HS Code: 12345677
DetailsTenofovir
CAS: 147127-20-6
MF: C9H14N5O4P
MW: 287.21
mp 276-280°C
storage temp. Store at -20°C
Water Solubility 13.4 mg/mL (25 oC)
Chemical Properties White Crystalline Solid
Usage Acyclic phosphonate nucleotide analogue. Used as an anti-HIV agent
Usage Acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral.
Purity: 99%
Usage: API
Package: 1KG foil bag; 25Kg drum
Description
Tenofovir is indicated for the treatment of HIV, HBV infection. This product also can cooperated with other reverse transcriptase inhibitors for HIV-1 infection and hepatitis BÂ treatment.
Adverse effects
1.The most common side effects associated with Tenofovir include asthenia.
2.Tenofovir has also been implicated in mild to moderate gastrointestinal reactions such as nausea, vomiting, diarrhea, and asthenia. Less frequent side effects include hepatotoxicity, abdominal pain, and flatulence,bloating, lactic acidosis, hepatomegaly with fatty liver, pancreatitis and so on. these adverse effects are common with the use of nucleoside analogues either separately or when combined with other drugs.
3.Tenofovir can also lead to metabolic system hypophosphatemia (1% incidence); fat accumulation and redistribution, including central obesity, buffalo hump, peripheral wasting, breast enlargement, Cushing syndrome.
4.Tenofovir may cause lactic acidosis, hepatomegaly with steatosis-related and so on.
5.Tenofovir may make nervous system: dizziness, headache.
6.Tenofovir sometimes leads to respiratory system: dyspnea.
7.Tenofovir may cause skin herpes.
Pharmacokinetics
Tenofovir is hardly absorbed through the gastrointestinal tract, for this reason, prodrug of Tenofovir has been developed by esterification, and then to make tenofovir fumarate ester. Tenofovir ester is water-soluble, can be rapidly absorbed and degraded into the active tenofovir, and then was metabolized to the active Tenofovir disoproxil. Tenofovir will reach the peak of plasma Concentration within 1-2 h after administration. When combined with food service, the bioavailability of Tenofovir can be increased by 40%. Intracellular half-life of Tenofovir disoproxil is about 10 h, it needs dosing everyday. Because Tenofovir is not a CYP-450 substrate, this may decrease the possibility of interactions with other drugs caused by CYP450. Elimination of Tenofovir is by glomerular filtration and active tubular secretion. Approximately 70% to 80% is recovered in urine as unchanged drug. Elimination half-life is approximately 17 h.
COA
| ITEMS | SPECIFICATION | TESTRESULTS |
| Appearance | Off-white or white powder | Conforms |
| Identification | HPLC,NMR;LC-MS | Conforms |
| Related substances | Individual impurity≤0.5% | 0.09% |
| Total impurities≤1.0% | 0.20% | |
| Loss on drying | ≤0.5% | 0.3% |
| Residue on ignition | ≤0.1% | 0.04% |
| Heavy metals | ≤10ppm | Conforms |
| Assay | ≥98.0 % | 99.1% |
Our advantage
a.Rich experience.We are a professional manufacturer in China for many years,our products have exported to Germany,Spain,UK,USA,Australia,Middle East and so many other countries,and we have got very good feedback from our customers,we had Established many long friendly relations of cooperation.
b.Great quality,purity and competitive price.Different country with different and suitable way of packing.Packing pictures will be sent to you as soon as possible after your payment.
c.Safe and fast delivery.We will send you with a safest and most suitable channel.
d.Good after-sales service.Our purpose is to hold a long friendly cooperation with our customers,so we will offer you best service from start to finish.
 Details
Tenofovir
CAS: 147127-20-6
MF: C9H14N5O4P
MW: 287.21
mp 276-280°C
storage temp. Store at -20°C
Water Solubility 13.4 mg/mL (25 oC)
Chemical Properties White Crystalline Solid
Usage Acyclic phosphonate nucleotide analogue. Used as an anti-HIV agent
Usage Acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral.
Purity: 99%
Usage: API
Package: 1KG foil bag; 25Kg drum
Description
Tenofovir is indicated for the treatment of HIV, HBV infection. This product also can cooperated with other reverse transcriptase inhibitors for HIV-1 infection and hepatitis BÂ treatment.
Adverse effects
1.The most common side effects associated with Tenofovir include asthenia.
2.Tenofovir has also been implicated in mild to moderate gastrointestinal reactions such as nausea, vomiting, diarrhea, and asthenia. Less frequent side effects include hepatotoxicity, abdominal pain, and flatulence,bloating, lactic acidosis, hepatomegaly with fatty liver, pancreatitis and so on. these adverse effects are common with the use of nucleoside analogues either separately or when combined with other drugs.
3.Tenofovir can also lead to metabolic system hypophosphatemia (1% incidence); fat accumulation and redistribution, including central obesity, buffalo hump, peripheral wasting, breast enlargement, Cushing syndrome.
4.Tenofovir may cause lactic acidosis, hepatomegaly with steatosis-related and so on.
5.Tenofovir may make nervous system: dizziness, headache.
6.Tenofovir sometimes leads to respiratory system: dyspnea.
7.Tenofovir may cause skin herpes.
Pharmacokinetics
Tenofovir is hardly absorbed through the gastrointestinal tract, for this reason, prodrug of Tenofovir has been developed by esterification, and then to make tenofovir fumarate ester. Tenofovir ester is water-soluble, can be rapidly absorbed and degraded into the active tenofovir, and then was metabolized to the active Tenofovir disoproxil. Tenofovir will reach the peak of plasma Concentration within 1-2 h after administration. When combined with food service, the bioavailability of Tenofovir can be increased by 40%. Intracellular half-life of Tenofovir disoproxil is about 10 h, it needs dosing everyday. Because Tenofovir is not a CYP-450 substrate, this may decrease the possibility of interactions with other drugs caused by CYP450. Elimination of Tenofovir is by glomerular filtration and active tubular secretion. Approximately 70% to 80% is recovered in urine as unchanged drug. Elimination half-life is approximately 17 h.
COA
| ITEMS | SPECIFICATION | TESTRESULTS |
| Appearance | Off-white or white powder | Conforms |
| Identification | HPLC,NMR;LC-MS | Conforms |
| Related substances | Individual impurity≤0.5% | 0.09% |
| Total impurities≤1.0% | 0.20% | |
| Loss on drying | ≤0.5% | 0.3% |
| Residue on ignition | ≤0.1% | 0.04% |
| Heavy metals | ≤10ppm | Conforms |
| Assay | ≥98.0 % | 99.1% |
Our advantage
a.Rich experience.We are a professional manufacturer in China for many years,our products have exported to Germany,Spain,UK,USA,Australia,Middle East and so many other countries,and we have got very good feedback from our customers,we had Established many long friendly relations of cooperation.
b.Great quality,purity and competitive price.Different country with different and suitable way of packing.Packing pictures will be sent to you as soon as possible after your payment.
c.Safe and fast delivery.We will send you with a safest and most suitable channel.
d.Good after-sales service.Our purpose is to hold a long friendly cooperation with our customers,so we will offer you best service from start to finish.
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