Effective Top Quality Anti-Fibrosis Drug Pirfenidone 53179-13-8 for Health Treatment

Effective Drug Pirfenidone 53179-13-8 For Treat Disease Idiopathic Pulmonary Fibrosis


Pirfenidone
CAS: 53179-13-8
Solubility: DMSO: 10 mg/mL, soluble
Appearance: White crystal powder
Melting Point: 102--109
Loss on drying: <1.0%
Known single impurity: <1.0%
Unknown single impurity: <0.5%
Total impurity: <2.0%
Assay(as dried): 99%min


Overview

Pirfenidone (PFD) is a novel kind of pyridine ketones which has a broad-spectrum anti-fibrotic effect, being able to prevent and reverse the formation of fibrosis and scar. It into into market in Shionogi, Japan in 2008 and has been approved by the US drug and Drug Administration. It is the first drug which has gone through phase III clinical trials (including repeating, randomized, and placebo-control) which has its effectiveness in treatment idiopathic pulmonary fibrosis (IPF); moreover, the drug has relative good efficacy in treatment some fibrotic diseases such as renal interstitial fibrosis and liver fibrosis. accident, it is also extensive applied in the phase II clinical study in kidney disease (focal segmental glomerulosclerosis), hypertrophic cardiomyopathy, adult type I neurofibromatosis, of neurofibromatosis and plexiform neurofibromas, diabetes union with kidney disease.


Clinical application

1. Idiopathic pulmonary fibrosis degeneration
Idio-pathic pulmonary fibrosis (idio-pathic pulmonary fibrosis, IPF) is a cause of unknown, poor prognosis, high mortality of chronic inflammatory interstitial lung disease, and PFD is an anti-inflammatory, anti-fibrosis agents, Can be used for the treatment of IPF.
2. liver fibrosis
3. Renal fibrosis
4. Multiple sclerosis
Multiple sclerosis (multiple sclerosis, MS) is associated with central nervous system and immune-related inflammation and demyelinating disease. The associated immune factors are the activation of stellate cells, glial cells, endothelial cells and lymphocytes, whereas PFD has the ability to inhibit cell activation.
5. Myocardial fibrosis
Cardiovascular diseases such as hypertension, cardiomyopathy and atrial fibrillation can lead to fibrosis of the myocardium, and thus the deterioration of the disease or the development of PFD treatment of sexual levator dystrophy caused by cardiomyopathy, can inhibit myocardial fibrosis, improve Heart function. PFD reduces myocardial remodeling and atrial fibrillation by inhibiting fibrosis.
6. Tumor disease: neurofibroma, uterine leiomyoma, malignant glioma.
7. Prevention of fibrosis after organ transplantation
8. Rheumatoid arthritis


Pharmacological effects

PFD is a potent inhibitor of a cytokine by regulating or inhibiting certain factors, thus inhibiting the biological activities of fibroblast cells and reducing the cell proliferation and the synthesis of collagen matrix. Meanwhile, PFD can also inhibit the secretion of inflammatory mediators, reduce lipid peroxidation, and exert its anti-inflammatory and antioxidant effects. 

1. Inhibition of collagen synthesis
Fibroblast growth factor (bFGF), transforming growth factor-β (transforming growth factor-β, TGF-β), connective tissue growth factor (connective tissue growth factor, CTGF) and tissue inhibitor of metalloproteinase 1 (TIMP-1) are growth factors that related with fibrotic diseases. They can promote fibroblast proliferation and growth, increase the synthesis of collagen matrix and prevent the degradation of extracellular matrix (ECM). They are expressed to different extent during the formation of organ fibrosis. PFD can effectively reduce the expression of the proteins such as bFGF, TGF-β, CTGF and TIMP-1 in the fibroblast cells of lung and kidney and be correlated with the reduction of collagen synthesis and matrix.
The formation of I and III type collagen fibers is also closely related to the synthesis of collagen matrix. At the same time of reducing TGF-β expression, PFD can also reduce the generation α I collagen. PFD also inhibit the expression of pulmonary fibrosis I collagen. In addition, PFD also has inhibitory effect on the expression of type III collagen mRNA and can reduce the synthesis of collagen type III.

2. The anti-inflammatory effects
PFD can inhibit to the inflammatory mediators to varying degrees for exerting their anti-inflammatory effects. When the inflammatory cytokines is overexpressed inside the lung, the inflammation reaction is exacerbated, thus making alveolar wall being thickening, reducing the function of pulmonary alveoli, and ultimately causing fibrosis. PFD primarily take anti-inflammatory effects by inhibiting the expression of inflammatory mediators, reducing vascular permeability, and reducing the agglomeration of neutropenia and inflammatory cells, thus further preventing or slowing down the fibrosis of organs and tissues.

3. Anti-oxidation effect
PFD mainly exert their antioxidant effects by scavenging free radicals and inhibiting lipid peroxidation and oxidative stress mitigation.
 



Delivery Terms

Delivery Time: Within 12 hours upon receipt of payment;
Shipping time: 3-7 working days (Door-to-Door);
Package pictures: Photos of parcel would be offered;
Tracking number:  Offered once it is delivered;
 
Payment ways: Bank Transfer, Western Union, Money Gram and Bitcoin;
Delivery ways: All Express Modes( EMS, DHL, TNT, FedEx, UPS, TOll etc.);
Packing: Select best ways according to quantity and safety degree( Super discreet, professional and experienced);
 
After-sale service: 24/7 Online for any problems;
Gurantee: Resend the goods if caught by customs.
  Effective Drug Pirfenidone 53179-13-8 For Treat Disease Idiopathic Pulmonary Fibrosis


Pirfenidone
CAS: 53179-13-8
Solubility: DMSO: 10 mg/mL, soluble
Appearance: White crystal powder
Melting Point: 102--109
Loss on drying: <1.0%
Known single impurity: <1.0%
Unknown single impurity: <0.5%
Total impurity: <2.0%
Assay(as dried): 99%min


Overview

Pirfenidone (PFD) is a novel kind of pyridine ketones which has a broad-spectrum anti-fibrotic effect, being able to prevent and reverse the formation of fibrosis and scar. It into into market in Shionogi, Japan in 2008 and has been approved by the US drug and Drug Administration. It is the first drug which has gone through phase III clinical trials (including repeating, randomized, and placebo-control) which has its effectiveness in treatment idiopathic pulmonary fibrosis (IPF); moreover, the drug has relative good efficacy in treatment some fibrotic diseases such as renal interstitial fibrosis and liver fibrosis. accident, it is also extensive applied in the phase II clinical study in kidney disease (focal segmental glomerulosclerosis), hypertrophic cardiomyopathy, adult type I neurofibromatosis, of neurofibromatosis and plexiform neurofibromas, diabetes union with kidney disease.


Clinical application

1. Idiopathic pulmonary fibrosis degeneration
Idio-pathic pulmonary fibrosis (idio-pathic pulmonary fibrosis, IPF) is a cause of unknown, poor prognosis, high mortality of chronic inflammatory interstitial lung disease, and PFD is an anti-inflammatory, anti-fibrosis agents, Can be used for the treatment of IPF.
2. liver fibrosis
3. Renal fibrosis
4. Multiple sclerosis
Multiple sclerosis (multiple sclerosis, MS) is associated with central nervous system and immune-related inflammation and demyelinating disease. The associated immune factors are the activation of stellate cells, glial cells, endothelial cells and lymphocytes, whereas PFD has the ability to inhibit cell activation.
5. Myocardial fibrosis
Cardiovascular diseases such as hypertension, cardiomyopathy and atrial fibrillation can lead to fibrosis of the myocardium, and thus the deterioration of the disease or the development of PFD treatment of sexual levator dystrophy caused by cardiomyopathy, can inhibit myocardial fibrosis, improve Heart function. PFD reduces myocardial remodeling and atrial fibrillation by inhibiting fibrosis.
6. Tumor disease: neurofibroma, uterine leiomyoma, malignant glioma.
7. Prevention of fibrosis after organ transplantation
8. Rheumatoid arthritis


Pharmacological effects

PFD is a potent inhibitor of a cytokine by regulating or inhibiting certain factors, thus inhibiting the biological activities of fibroblast cells and reducing the cell proliferation and the synthesis of collagen matrix. Meanwhile, PFD can also inhibit the secretion of inflammatory mediators, reduce lipid peroxidation, and exert its anti-inflammatory and antioxidant effects. 

1. Inhibition of collagen synthesis
Fibroblast growth factor (bFGF), transforming growth factor-β (transforming growth factor-β, TGF-β), connective tissue growth factor (connective tissue growth factor, CTGF) and tissue inhibitor of metalloproteinase 1 (TIMP-1) are growth factors that related with fibrotic diseases. They can promote fibroblast proliferation and growth, increase the synthesis of collagen matrix and prevent the degradation of extracellular matrix (ECM). They are expressed to different extent during the formation of organ fibrosis. PFD can effectively reduce the expression of the proteins such as bFGF, TGF-β, CTGF and TIMP-1 in the fibroblast cells of lung and kidney and be correlated with the reduction of collagen synthesis and matrix.
The formation of I and III type collagen fibers is also closely related to the synthesis of collagen matrix. At the same time of reducing TGF-β expression, PFD can also reduce the generation α I collagen. PFD also inhibit the expression of pulmonary fibrosis I collagen. In addition, PFD also has inhibitory effect on the expression of type III collagen mRNA and can reduce the synthesis of collagen type III.

2. The anti-inflammatory effects
PFD can inhibit to the inflammatory mediators to varying degrees for exerting their anti-inflammatory effects. When the inflammatory cytokines is overexpressed inside the lung, the inflammation reaction is exacerbated, thus making alveolar wall being thickening, reducing the function of pulmonary alveoli, and ultimately causing fibrosis. PFD primarily take anti-inflammatory effects by inhibiting the expression of inflammatory mediators, reducing vascular permeability, and reducing the agglomeration of neutropenia and inflammatory cells, thus further preventing or slowing down the fibrosis of organs and tissues.

3. Anti-oxidation effect
PFD mainly exert their antioxidant effects by scavenging free radicals and inhibiting lipid peroxidation and oxidative stress mitigation.
 



Delivery Terms

Delivery Time: Within 12 hours upon receipt of payment;
Shipping time: 3-7 working days (Door-to-Door);
Package pictures: Photos of parcel would be offered;
Tracking number:  Offered once it is delivered;
 
Payment ways: Bank Transfer, Western Union, Money Gram and Bitcoin;
Delivery ways: All Express Modes( EMS, DHL, TNT, FedEx, UPS, TOll etc.);
Packing: Select best ways according to quantity and safety degree( Super discreet, professional and experienced);
 
After-sale service: 24/7 Online for any problems;
Gurantee: Resend the goods if caught by customs.
 

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