Release date: 2017-02-20
Scientists have been exploring the mechanisms that make the weight loss process so complicated. Exercise can burn calories, and scientists are also studying how the body burns more energy to keep warm at low temperatures. So is there a way to increase metabolism – even if it's not in a cold environment?
Professor Anutosh Chakraborty of TSRI has achieved some results in exploring the answers to the above questions. His past research has revealed a new target for the treatment of obesity, in which they found a protein that promotes fat accumulation by reducing energy expenditure, leading to weight gain.
In a recent study published in the international academic journal Molecular Metabolism, Chakraborty and his team of researchers found that deleting the gene that expresses this protein, IP6K1, protects animal models against obesity and diabetes. This protection can be observed even at hot neutral temperatures, regardless of diet. This means that regardless of the external environment, inhibiting IP6K1 can help animals burn more energy.
Temperature is an important factor in obesity research. Animals can burn more energy in order to maintain core body temperature in a lower temperature environment and thus can lose weight more quickly. Because humans can maintain body temperature in a variety of ways—such as wearing clothes—any signaling pathway that promotes weight loss at higher temperatures is promising as a potential target for treating human obesity.
The new study suggests that the development of a drug targeting IP6K1 in the future may mimic the energy-consuming process in low-temperature environments.
"If we delete the IP6K1 gene, the animal model will resist the increase in body weight by consuming more energy, regardless of the temperature of the outside world. This is very important because it is resistant to weight gain by increasing energy expenditure at hot neutral temperatures. Very difficult, so targeting IP6K1 is expected to be successful in the treatment of human obesity," Chakraborty said.
"If an obesity treatment is developed based on inhibition of IP6K1, our new findings suggest that there may be almost no restrictions on the use of this drug. With this drug, even if you eat high-fat foods, you can lose weight without sitting. In the cold storage, you can lose weight by increasing energy consumption," he added.
Source: Bio Valley (micro signal BIOONNEWS)
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