According to foreign media reports, scientists have successfully cultivated "perfect" human blood vessels in the laboratory for the first time. This breakthrough will have a major impact on the study of a variety of vascular diseases, including diabetes, allowing researchers to test new drugs more easily and conveniently.
The three-dimensional structure of the blood vessel "organs" created by the research team
The so-called "vascular organs" are cultivated in the laboratory using stem cells, and are strikingly similar to the structure and function of real human blood vessels. After the researchers transplanted the vascular organ into the mouse, these artificial blood vessels successfully developed into well-functioning blood vessels, including arteries and capillaries. This finding shows that we can not only grow vascular organs with human stem cells in culture dishes, but also develop them into a functioning human vascular system in another organism.
This breakthrough technology has been published in the journal Nature. The discovery also points us to a new way to prevent vascular changes. Vascular changes are one of the leading causes of death and symptoms of diabetes.
Reiner Wimmer, the first author of the study, said, “The most exciting thing about our work is that we have succeeded in using stem cells to create real human blood vessels, and we have created vascular organs and Human capillaries are very similar, and the similarity is even at the molecular level. Now we can use these artificial blood vessels to study vascular diseases directly on human tissues."
Josef Penninger, senior research author and director of the Institute of Life Sciences at the University of British Columbia, said, “It is of great significance to be able to grow human blood vessels from stem cells . Every organ in the body is closely related to the circulatory system. This breakthrough is expected to help researchers find the causes and therapies for a variety of vascular diseases such as Alzheimer's, cardiovascular disease, wound healing, stroke, cancer, and of course diabetes."
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