New drugs can make mouse cancer cells "sleep" permanently
August 17, 2018 Source: Chinese Journal of Science
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Not long ago, Australian scientists took a major step in the field of cancer research. They discovered a new type of drug that can prevent cancer cells from splitting and proliferating in mice, and put the cancer cells of animals into a permanent sleep state. Effectively prevent the progression of blood cancer and liver cancer in mice and delay the recurrence of cancer. The research results are mainly from the Walter and Eliza Hall Medical Research Institutes in Australia and published in the journal Nature.
It is reported that this is the first drug in the development of such new drugs in the past decade to prevent cancer cells from multiplying, without causing harmful side effects like traditional cancer treatment.
“As a new weapon against cancer, we are very excited about its enormous potential,†said Tim Thomas, an associate professor at the Walter and Eliza Hall Medical Institute. “These drugs are well tolerated in our preclinical models. It is very effective against tumor cells."
Conventional chemotherapy can cause irreversible damage to cancer cell DNA and can also destroy healthy cells. These new drugs can block the production of specific proteins that promote the growth of cancer cells. "Blocking them 'trigger' the ability of the cell cycle to begin to stop cancer cell division," said co-author Anne Voss, associate professor. "The cells are not dead, but they can no longer divide and proliferate, and cancer cell division is effectively prevented. ."
“The drugs we are developing are just a proof of concept. The next step is to develop a more suitable new drug that can be used in cancer patients. It is too early to use in the clinic.†Thomas said that many large pharmaceutical companies have tried to develop inhibition in the past. Cellular mechanisms of the drug have not been successful.
Darren Saunders, a cancer biologist at the University of New South Wales, said the study is particularly important because there are many genes involved in cancer growth, "it is difficult to develop therapeutic drugs."
“This is a protein that is particularly difficult to target and is even considered difficult to develop.†Darren Saunders said that they started the work 10 years ago and screened nearly 250,000 different compounds, with 52 involved. .
Dr. Thomas said that in the future, they will seek industry partners to incorporate new drug concepts into clinical trials. (Wang Fei)
Related paper information: DOI: 10.1038/s41586-018-0387-5
Chinese Journal of Science (2018-08-17 8th Edition Health)
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