In the recent "Nature·Biotechnology", the results of the Chinese National Science Center of the Chinese Academy of Sciences and the University of Arizona State University (ASU) team of scientists are eye-catching: scientists use DNA origami technology to create the world's first intelligent anti-cancer Nano-robots, which can find blood vessels that supply blood to tumors in the human body, and then release drugs to create blood vessels that block blood vessels, thereby "starving" tumors, and show good efficacy and safety in animal experiments.
Cancer cells reduce the body's nutrients in large quantities, while blood vessels provide blood for cancer cells to supply blood, supply oxygen, and supply energy. Therefore, blocking the supply of blood vessels in solid tumors and starving for cancer cells has always been the main direction for scientists to treat cancer. For example, arterial embolization chemotherapy (TACE), which is commonly used in the treatment of liver cancer, is directed at the hepatic artery that supplies blood to the tumor, but this method also faces the problem of insufficient precision and side effects.
Since 5 years ago, the team of the National Nanoscience Center of the Chinese Academy of Sciences, led by Academician Zhao Yuliang and Ding Baoquan and Nie Guangjun, decided to try to induce thrombosis.
Professor Yan Wei from his team said: "We have designed the world's first fully autonomous precision drug delivery, targeted therapy DNA robot system, which is a major advancement in DNA nanotechnology in the field of cancer treatment. I think this The technology is very close to being put into practical use. The specially designed nano-robot is equipped with various drugs, and it is expected to completely eliminate solid tumors and blood-rich metastases, which achieves the ultimate goal of cancer treatment. Moreover, this robot The treatment strategy can also be used as a platform for the treatment of other diseases.†The research team is already looking for partners to transform the results of this laboratory.
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