Release date: 2015-04-23
Researchers at the Institute of Zoology of the Chinese Academy of Sciences have recently discovered key inflammatory factors for lung cancer caused by smoking. Related results were published in the journal Cancer News.
The data show that 90% of the nearly 1.6 million lung cancer deaths each year are caused by smoking. Tobacco contains 5,000 compounds, 73 of which are carcinogenic to experimental animals and humans. Smoking can cause DNA damage and gene mutations, but the mechanism of smoking-induced lung cancer remains unclear, and this is a prerequisite for the development of lung cancer prevention and treatment strategies.
The researchers treated human lung epithelial cells with tobacco carcinogen nicotine-derived nitrosamine for 60 days, and then detected changes in 84 cytokines and chemokines. In normal lung epithelial cells, nicotine-derived nitrosamines can be used. The expression level of the chemokine ccl20 was significantly increased. They examined the expression of ccl20 in cancer tissues of lung cancer patients and found that in 92 patients with lung cancer, 48 patients had elevated ccl20 expression. Among the 78 non-smokers, 29 had high expression of ccl20. This indicates that the expression level of ccl20 is related to smoking.
Studies have shown that the higher the expression of ccl20, the shorter the patient's survival time. In cells and experimental animals, nicotine-derived nitrosamines promote the proliferation and metastasis of lung cancer cells by inducing the expression of ccl20. Anti-inflammatory drugs inhibit the expression of ccl20 and inhibit the growth of lung cancer cells. These results indicate that ccl20 is not only a key inflammatory factor for lung cancer caused by smoking, but also a new target for the treatment of lung cancer.
Source: Chinese Journal of Science
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