Instructions for use of betel nut four pills (water pill)

The source of the prescription is the Chinese Pharmacopoeia (2000 edition).
Formulated pills
The drug composition is 200g of betel nut, 400g of rhubarb (wine fried), 400g of fried beef (fried), 50g of pork tooth soap (fried), 200g of fragrant vinegar (made of vinegar), and 200g of Wulingzhi (vinegar fried).
Add or subtract
Efficacy digestion and stagnation, qi and water.
Indications for food and drink, indigestion, abdominal distension, phlegm and swallow acid, constipation.
The preparation method pulverizes into fine powder, sifts, mixes, pans with water, and is dried, that is, it is obtained.
Usage and dosage 6g each time, 2 times a day orally.
Drug contraindications pregnant women should not take it.
Adverse reactions were reported in 7 cases of diarrhea after taking the drug, but gradually improved with the relief of the disease, and one of the cases was severely treated with ginseng and spleen pills.
Clinical application
Pharmacological effects mainly increase intestinal motility, antispasmodic, antibacterial and anti-inflammatory effects.
1. Increase intestinal peristalsis: betel nut, beetle has increased intestinal peristalsis.
2. Solution: Rhubarb, Wulingzhi, and Xiang have the effect of relieving smooth muscle spasm.
3. Antibacterial, anti-inflammatory: areca nut, rhubarb. Wulingzhi and Xiang have antibacterial and anti-inflammatory effects.
Toxicity test
chemical composition
Physical and chemical properties This product is light brown to brown water pill; gas is slightly fragrant, bitter and spicy. Should comply with the relevant provisions under the pill.
(l) Take this product and observe under the microscope: the calcium oxalate cluster crystal diameter is 60-140μm. The secretory cells are round, containing yellowish brown to reddish brown secretions, and the surrounding cells are arranged radially; the fiber bundle is reddish brown or yellowish brown, slender, and the wall is very thick. The fiber bundle is light yellow, and the surrounding cells contain calcium oxalate crystals and a few cluster crystals, forming crystal fibers, often accompanied by square-shaped thick-walled cells. The seed coat cells are light brown or brown and 48-80 μm long. The endosperm fragments are colorless, the walls are thicker, and there are more large rounded holes.
(2) Take 0.5g of this product, add 20ml of methanol, immerse for 1 hour, filter, take 5ml of filtrate, evaporate dry, add 10ml of water to dissolve the residue, add 1ml of hydrochloric acid, heat on water bath for 30 minutes, cool immediately, use ether The extract was extracted twice, 10 ml each time, and the ether extract was combined, evaporated to dryness, and dissolved in 1 ml of chloroform to dissolve as a test solution. Another 0.1 g of rhubarb reference medicine was prepared, and the same method was used to prepare a reference medicine solution. According to the thin-layer chromatography test, 4 μl of each of the above two solutions was aspirated and placed on the same silica gel H thin plate with sodium carboxymethyl cellulose as a binder to petroleum ether (30-60 ° C)-ethyl formate. The upper layer solution of formic acid (15:5:1) was used as a developing solvent, developed, taken out, air-dried, and examined under an ultraviolet lamp (365 nm). In the chromatogram of the test sample, the same five orange fluorescent spots were observed at the positions corresponding to the chromatogram of the reference drug; after the smoke was set in the ammonia vapor, the spots turned red.

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