The reporter learned from the Chinese Academy of Sciences that China has made breakthroughs in the field of stem cell intervention in the study of premature ovarian failure. On the morning of the 12th, Ms. Fang, 34 years old with premature ovarian failure, successfully gave birth to the first healthy baby boy at Nanjing Gulou Hospital.
Ms. Fang is an Anhui native who has not been pregnant for 3 years and has been inspected by local hospitals for ovarian failure leading to infertility. For a round mother's dream, she has failed to treat the hospital in many hospitals across the country for many years. In December 2015, she went to Nanjing Gulou Hospital for medical treatment. Dr. Sun Haixiang, Professor of Reproductive Medicine Center of Drum Tower Hospital, teamed up with Professor Dai Jianwu from the Institute of Genetics and Development of the Chinese Academy of Sciences to use stem cell regenerative medicine technology to improve ovarian blood flow and repair ovarian function, and restore ovarian follicle activity in May last year, eventually achieving natural pregnancy.
Conquering premature ovarian failure with infertility marks a breakthrough in the clinical research of ovarian regeneration in Gulou Hospital. The scientific research results are the first stem cell clinical research project filed by China's first health planning committee. It is the field of reproductive medicine after the repair of endometrial damage. Another major breakthrough has once again announced the staged victory of regenerative medicine technology to overcome the "incurable disease" of the reproductive system.
Premature ovarian failure (POF) refers to the occurrence of ovarian failure in women due to various causes before the age of 40. The incidence rate in women of childbearing age exceeds 1%, and the incidence rate has increased and rejuvenated in recent years, which is considered to be the cause of infertility. incurable disease". Sun Haixiang, director of the Reproductive Medicine Center of Nanjing Gulou Hospital, told reporters that patients with premature ovarian failure due to ovarian failure, even through assisted reproductive technology, it is difficult to achieve conception, because these patients have no dominant follicular activity in the menstrual cycle, unable to obtain eggs. "Popular point of view, premature ovarian failure is like a flower withered from the rhizome, no good seeds (egg), how can you bear a sweet fruit (fetus)? Therefore, the key to solving this part of the patient's infertility is how to save the ovarian function Obtaining high-quality eggs for embryos. Currently, estrogen and progesterone replacement therapy is a routine method for treating such diseases, but the results are minimal."
Under the support of the Chinese Academy of Sciences stem cell and regenerative medicine research, the Reproductive Medicine Center of Nanjing Gulou Hospital cooperated with the Dai Jianwu Regenerative Medicine Research Team of the Institute of Genetics and Development of the Chinese Academy of Sciences. In 2015, it took the lead in the international development of umbilical cord mesenchymal stem cells to interfere with premature ovarian failure. Clinical study of pregnancy. After passing the hospital ethics review and filing with the National Health Planning Commission, the clinical research became one of the first eight stem cell clinical research projects after the implementation of the stem cell clinical research filing system in China, and was officially launched in Nanjing Gulou Hospital.
It is understood that Dai Jianwu's team has long been engaged in research on regenerative medicine, breaking through the key core technologies of regenerative medicine, and has made major breakthroughs in clinical research such as endometrial regeneration and spinal nerve regeneration. In order to solve this "incurable disease" on the ovary, Dai Jianwu team designed an injectable intelligent collagen scaffold material for ovarian function regeneration. The Reproductive Medicine Center of Nanjing Gulou Hospital cooperated with Dai Jianwu's regenerative medicine research team to confirm that umbilical cord mesenchymal stem cells combined with collagen scaffold materials can accelerate primordial follicle activation through phosphorylation follicle developmental key elements FOXO3a and FOXO1 through a large number of in vitro and animal experiments. And granulosa cell proliferation. Stem cells can also secrete a variety of cytokines, such as VEGF, HGF, IGF-I, etc., through the paracrine pathway involved in regulating granulosa cell growth, apoptosis, repair premature ovarian. The umbilical cord mesenchymal stem cells are attached to the degradable collagen scaffold material, and the scaffold is used to help the stem cells colonize and differentiate, activate the primordial follicles, repair the premature ovary, and enable the female with premature ovarian failure to regain fertility.
According to the relevant person in charge of Drum Tower Hospital, in December 2015, Dr. Sun Haixiang, professor of the reproductive center of Nanjing Gulou Hospital, conducted a stem cell ovarian transplantation for Ms. Fang. The umbilical cord mesenchymal stem cells were prepared by the GMP-level clinical stem cell chamber of Gulou Hospital. Third-party inspection by China Food and Drug Administration. After the operation, the ovarian blood flow was significantly improved. In 2016, Ms. Fang performed two transplants. In May 2017, Ms. Fang was confirmed to have a large follicular activity, and she was naturally conceived in the month. In the past two years, 23 patients have been enrolled in the clinical study. During the follow-up, 9 patients have dominant follicular activity. Two patients have obtained clinical pregnancy. Two patients have obtained transplantable embryos and are preparing for endometrial transplantation. .
Industry experts said that this breakthrough in clinical research on ovarian regeneration has also provided new technical means for ovarian dysfunction and ovarian anti-aging in older women. (People's Network)
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