Release date: 2017-11-06
The Japanese research team has recently successfully developed a nanomachine using amino acids, which can smoothly pass drugs into the brain through the barrier of the blood-brain barrier (BBB) ​​in the brain. It is expected to be used in the treatment of Alzheimer's disease in the future. Brain disease.
Because there are blood-brain barriers in the human brain, in addition to nutrient sources such as glucose, substances in the blood can hardly enter the brain, which makes it difficult for the body's diseases to invade the brain, but it also makes it difficult to use drugs to treat brain diseases.
The research team "COINS" consisting of the University of Tokyo and the Tokyo Medical and Dental University has successfully developed a nano-robot with a diameter of only 30 nanometers (nm), a surface covered with glucose, and specific proteins and glucose in the blood vessels of the brain. Once combined, the drug can be transported to the brain through the blood-brain barrier.
The research team also found that in the fasting state, certain proteins in the brain began to actively transport glucose. The team used this feature to use nano robots in fasting rats, and the drugs were not only successfully delivered to the brain, but also more effective than conventional drugs. It is about 100 times.
The research team believes that through the use of this technology, in the future, some brain diseases can be expected to see an unprecedented therapeutic effect.
Yokota Ronda, a professor at Tokyo Medical and Dental University, believes that this nano-robot can be used to treat Alzheimer's disease, and it is also a powerful weapon for the treatment of some nerve-related incurable diseases and mental illnesses.
One of the special professors of Dongda, Mr. Kataoka, said that the future research and development goal of nanotechnology is to send drugs to any place in the body.
The results of the study are currently published in the UK's Nature Communications.
Source: Technews Technology News
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