Release date: 2017-09-19
Researchers at the University of Saskatchewan are focusing on the development of bio 3D printed heart patches that can be used to regenerate and repair damaged heart tissue. A recent study published in the journal Tissue Engineering may be a major advancement in heart disease treatment research.
Researcher Mohammad Izadifar is a Ph.D. student in biomedical engineering at the University of Saskatchewan, Canada, specializing in heart disease and heart disease treatment research. His recent breakthrough research in bio 3D printing has tested animals and achieved positive results. 
“Mohammad's research is a groundbreaking work,†said Daniel Chen, director of mechanical engineering at Izadifar. “The initial results of using animal models are promising. This novel heart patch has the potential to benefit human patients around the world.â€
Impressively, Izadifar says his innovative 3D printed heart patch can be prepared for humans (at least in trials) over the next decade. His research goal is to completely change the course of treatment of heart disease.
When a person has a heart attack, some or all of the blood is blocked to a certain part of the vital organs. If this person is spared, the heart of the injury still cannot be resolved. In other words, healthy tissue cannot be naturally regenerated to fully restore the heart.
Izadifar explained: "The problem is that the heart can't repair its heart if it is damaged by a heart attack. If the heart tissue dies, it won't recover."
However, a heart patch can provide a solution to this problem. Izadifar has developed patches that can be printed using biocompatible materials and bio 3D printers. The patch consists of a "porous jelly-like structure" made of an algae-based hydrogel designed to dissolve in the patient's heart after implantation.
It is worth noting that 3D printed patches are designed to accommodate stem cells and biocompatible nanoparticles. These nanoparticles can be programmed to send signals to the blood vessels of the heart, effectively promoting and encouraging regrowth of damaged heart tissue.
More specifically, the nanoparticles in the bio-3D print scaffold promote the conversion of stem cells (also in the patch) into heart cells, which help to gradually regenerate the patient's own damaged heart and even help to create new blood vessels.
As Izadifar said: "With the help of this patch, patients will be able to regenerate heart tissue from their own cells. This will be a permanent solution for treating heart attacks."
So far, Izadifar has been able to implant his heart patch technology into mice for testing. To be able to monitor rats (the medical imaging system reported that the implant was invisible), the researchers worked with the Canadian Light Source (CLS) synchronizer to develop a non-invasive imaging process.
“With different 3D printing modes, we can control the toughness, conductivity and cell alignment of the patch. With the medical imaging technology developed by CLS, we can monitor the performance of 3D printed heart patches during heart healing,†he said. â€
The implantation process in rats was assisted by his co-director and neurosurgical specialist Michael Kelly. This test has shown promising results: mice implanted with 3D printed heart patches have a 70% survival rate (traditional surgery-like surgery with only 50% survival).
Currently, researchers are focusing on the long-term effects of 3D printed heart patches on rats. His research was supported by the Canadian Institute of Health.
Source: 3D Tiger
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