Release date: 2015-06-26
Mutations in the gene cause sperm deficiency, resulting in male infertility. Because of the lack of functional germ cells in the testes, these patients cannot have their own offspring through assisted reproductive technologies (such as IVF), and restoring their fertility is a big challenge.
Scientists from Nanjing Medical University and the Institute of Zoology of the Chinese Academy of Sciences have made important breakthroughs in this area. They combined cell reprogramming with genome editing to successfully create functional sperm in mutant mice lacking sperm and have their own offspring. The results were published in the June 19 issue of Cell Research. The author of the article was Qi Zhou, a researcher at the Institute of Zoology, Chinese Academy of Sciences, and Jiahao Sha, a professor at Nanjing Medical University, and a researcher at the Institute of Zoology, Chinese Academy of Sciences. Xiao-Yang Zhao.
Somatic cell nuclear transfer is mainly to transplant the cell nucleus of the donor cell into the egg cell from which the nucleus has been removed. Through such reprogramming, one can obtain embryos that match the donor cells. The researchers performed nuclear transfer of somatic cells from the Kitw/Kitwv mouse model to obtain nuclear transfer embryonic stem cells (ntESC).
Subsequently, they used TALEN for genome editing, corrected the gene mutations in ntESC, and further differentiated them into primord germ cell-like cells (PGCLC). Studies have shown that these PGCLCs can produce functional sperm in the mouse testis, supporting the development of offspring to full-term. This study shows a new way to help solve male infertility caused by genetic mutations.
Source: Biopass
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