Two cloned monkeys are born! Zhongzhong Huahua, which is the first monkey in the world to be successfully cloned using the cloned sheep Dolly technology. Two macaques were born less than 10 weeks and are currently very healthy. This is also a major breakthrough in the world of life sciences.
Their "story" is on the cover of the internationally authoritative academic journal Cell, which means that Chinese scientists have successfully broken through the world's problems that the existing technology cannot clone primates.
The female long-tailed macaque represents a technical milestone. It represents the ability to create customizable and genetically identical monkey populations that accelerate the treatment of diseases such as Parkinson's, Alzheimer's disease and cancer. But this breakthrough will inevitably raise concerns that cloning humans is closer than ever.
The Chinese team that cloned monkeys said that these monkeys have such great potential because they all inherit the same genetic material.
This will enable scientists to modulate monkey-related genes in human disease and then monitor how these changes alter the animal's biological properties and compare it to animals that are identical to the altered genes. The team said it could speed up the search for genes and processes that have gone wrong in these diseases, as well as ways to correct them.
Although 23 mammals have been cloned, including pigs, cats, dogs, mice and cattle, there has been no difficulty in overcoming the closest non-human primate clones to humans. Scientists have generally believed that prior art cannot clone primates.
In 2000, the researchers cloned monkeys for the first time, but by splitting the embryos after fertilization, basically only one twin with the same gene was produced. This method can only be used to create up to 4 identical animals.
Now, Sun Qiang and his colleagues at the Institute of Neuroscience of the Chinese Academy of Sciences in Shanghai have adjusted the technique used to clone Dolly, creating a theoretically unlimited number of clones.
Called somatic cell nuclear transfer, the method involves removing the nucleus from the donor egg cell and replacing it with a nucleus taken from the cells of another animal.
Current is used to deceive the egg, which is thought to have been fertilized and begins to develop into early embryos. When implanted in the uterus of an alternate mother, the embryo will grow as a copy of the animal that donated the nucleus (see figure).
Previous attempts to do this in monkeys have never broken through the early embryonic stages known as blastocysts.
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