Schematic diagram of anti-brain glioma after single intravenous injection of intelligent nano drug
The Lu Weiyue team of the School of Pharmacy of Fudan University collaborated with Zhang Liangfang of the University of California, San Diego to develop a new type of intelligent nano-drug for anti-brain tumors. It can maintain stability in the blood circulation for a long time, “circumvent†the blood-brain tumor barrier and directly cross the blood. - The brain tumor barrier reaches the destination (tumor tissue) that the drug cannot reach in the past, and more drugs are introduced into the brain tumor and released in the tumor cells, which accurately strikes the brain tumor, and has small toxic and side effects and high safety. Features. The results have been published online recently in the American Chemical Society ACS Nano ("ACS NANO").
Professor Lu Weiyue said that there are multiple physiological barriers in brain tumors. These barriers, like the walls, block foreign drugs from entering brain tumor tissues. That is, there is a blood-brain barrier in the early stage of brain tumors. After the formation of new blood vessels in the tumor tissue, a blood-brain tumor barrier appears. They allow nutrients to enter brain tissue and brain tumor tissue, but they can block the outside as a rock. The drug enters. At present, the treatment of brain tumors is mainly through surgical resection, but because brain tumors occur in the central nervous system and the tumor boundaries are blurred, it is difficult to completely remove the surgery, and the postoperative drug treatment is hindered by the physiological barrier, which makes the treatment effect poor and easily leads to brain tumor recurrence. Simply increasing the dose of chemotherapy will bring serious side effects, which will eventually lead to poor treatment compliance.
In order to solve the problem that drugs are difficult to "collect" the blood-brain tumor barrier, Lu Weiyue's research team and Zhang Liangfang's research team have cooperated and explored for many years, and decided to use high-loaded nanocrystalline technology, long-circulating cell membrane coating technology and lesions. The combination of targeted techniques for tissue navigation has finally led to the development of a new intelligent nanomedicine that can be used in the treatment of brain tumors. That is, the chemotherapeutic drug is first prepared into nanocrystals, and then mixed with the erythrocyte membrane equipped with the active navigation function molecule, so that the erythrocyte membrane is completely wrapped on the surface of the drug nanocrystal. At this time, the active navigation erythrocyte membrane wrapped outside the drug nanocrystals has excellent "camouflage", in which the protein and sugar base on the surface of the erythrocyte membrane is like the "pass" of the blood system of the body, which can deceive the reticuloendothelial system and immune system in vivo. Check to avoid being removed as "foreign matter", to ensure that the contained drug has a long enough circulation time in the blood and to remain stable in the blood circulation for a long time; the "camouflage coat" also has excellent targeting, ie Using active homing molecules assembled on the surface of erythrocyte membranes, the drug-borne drugs are directed across the blood-brain tumor barrier to brain tumor tissues and tumor cells, and the distribution of drugs in the lesion tissues and cells is improved; the method is safe, the reason The erythrocyte membrane can prevent the contained drug from leaking in the blood environment, reduce the systemic distribution of the drug, and is beneficial to improving the safety of the drug treatment and reducing the incidence of toxic and side effects.
Lu Weiyue said that the technology can effectively inhibit brain tumor growth by a single high-dose intravenous injection, and the preparation method and raw materials are simple, which is beneficial to industrialization. Zhang Liangfang said that the current equipment for blood transfusion can be used to obtain erythrocyte membrane materials. The successful development of extracorporeal blood cell culture technology also helps to promote the clinical transformation of this technology.
Related paper information: https://pubs.acs.org.ccindex.cn/doi/10.1021/acsnano.9b00661
Source: Science Network
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