The more itchy, the more itchy, the more itchy, the more weird
April 19, 2019 Source: Health News Network
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];The more you scratch, the more itchy, the more you want to scratch, what is the reason? Recently, Professor Xu Tianle's research group of Shanghai Jiaotong University School of Basic Medicine and the research team of Hu Wei, Shanghai University of Science and Technology, collaborated to answer from the neuroscience level. This study confirmed that GABAergic neurons and dopaminergic neurons in the ventral tegmental area of ​​the midbrain reward center regulate two different components of itch, respectively, that is, GABAergic neurons mediate the sensation caused by itch-causing agents. And dopaminergic neurons mediate the pleasure after scratching, deepen people's understanding of the mechanism of itch central loop, and provide new ideas for the treatment of clinical chronic itching. Relevant research results are published online in the international neuroscience academic journal Neuron.
Itching is a feeling that can cause a desire to scratch. At present, most researches on itch are concentrated in the peripheral and spinal cord levels, and there are relatively few studies on how the brain processes, encodes, and processes itch.
The researchers first used fiber recording technology and various transgenic mice to find that GABAergic neurons and dopaminergic neurons in the VTA region of the midbrain reward center exhibited two different activation responses during the itch process. GABAergic neurons can be transiently activated by acute itch stimulation, almost in sync with the onset of scratching, while dopaminergic neurons only activate after a period of scratching. Interestingly, activation of dopaminergic neurons was completely blocked by allowing mice to wear a self-made collar that prevented them from scratching the skin of the itch-injecting site, while activation of GABAergic neurons was more pronounced.
Next, the researchers manipulated two different types of neurons by optogenetic means and found that they could have different effects on the number of scratches and scratching intervals caused by acute itching. Further, through optogenetic manipulation and conditional position aversion or conditional position preference experiments, it was confirmed that two types of neurons in the VTA brain region regulate the two different components of itch, that is, GABAergic neurons mediate the itch-causing agent. The sense of disgust, while dopaminergic neurons mediate the pleasure of scratching. The study also found that VTA neurons also play a similar role in chronic itch animal models. These findings reveal the neural circuit mechanism of itching, scratching, itching, and scratching from a new perspective. (Special correspondent Yang Jing)
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