A team from the Department of Molecular Biophysics at the University of Lodz in Poland is studying the role of histone methylation in angiogenesis. The researchers found that if the overall inhibition of methyltransferases works, it inhibits angiogenesis. This discovery opens up new possibilities for chemotherapy.
Human endothelial cells have the natural ability to form blood vessels. This is important for blood system formation and carcinogenesis because capillaries and blood vessels provide nutrients and oxygen to every cell in the body. Due to the high metabolic rate and cleavage rate, mutant cells that cause cancer (which will become tumors over time) require more nutrients and oxygen. To ensure optimal growth, cancer cells stimulate endothelial cell proliferation and form a new network of capillaries. If you try to inhibit and slow down this pathological angiogenesis caused by cancer cells, the tumor can effectively fight cancer by lacking enough nutrients and rapid growth of oxygen.
The researchers tried AMI-1 and AMI-5 compounds that inhibit arginine and lysine methyltransferases. In addition to observing the effects of inhibiting methyltransferase activity to inhibit angiogenesis, they also observed other pathological changes in the nucleus that researchers hope to avoid. The next step in the research is to find more precise inhibitors that only inhibit angiogenesis without causing other nuclear aberrations.
The research team has conducted basic research on the cell line and the next phase is intended to be transferred to animal testing. At present, the world is looking for new anticancer drugs that can effectively remove and destroy cancer cells and have less toxicity to normal cells. (Technology Department)
Viral Transportation Medium Tube
Uses: used for the detection and sampling of influenza, hand, mouth, foot and other epidemic diseases
Inspection principle:
The combination of multiple antibiotics has broad-spectrum antibacterial and antifungal effects;
As a protein stabilizer, bovine serum albumin can increase the survival time and infection stability of the virus;
Buffers such as Hank's build a neutral environment, which helps to increase the survival time and infection stability of the virus;
Phenol red is an acid-base indicator, the discoloration area is 6.6 (yellow)~8.0 (red), and it is red at 7.2~7.4.
Steps:
1. According to the sampling requirements, use a sampling swab to collect samples.
2. Place the swab after collecting the sample into a sterile sampling tube.
3. Break the sampling swab rod that is higher than the sterile sampling tube.
4. Tighten the cap of the sterile sampling tube.
5. Label the sterile sampling tube with information as required.
For sample collection, transportation and storage.
Product advantages:
1. The virus discretion of the flocking swab is high to ensure the accuracy of the test results.
2. The samples are well sealed to ensure product transportation and safe storage.
3. Product instruction manual, product certificate
Product Details:
1. The product set includes a one-time Virus Sampling Tube (including preservation solution), a self-sealing bag, a sampling swab, and instructions.
2. Product specification: 100 sets/box, 8 boxes/box 3. Product weight: 0. 65kg/box, 13. 2kg/box
4. Packing size: 25. 5*23. 5*14. 5 boxes, 53*49*32/carton
Scope of application:
Work resumption testing, the best choice for large-scale population screening
Features:
1. Transport at room temperature, stably preserve viral RNA
2. Pre-packaged guanidine salt lysate can inactivate the new coronavirus, ensuring the safety of transportation and testing personnel 3. The large-capacity preservation solution can fully soak the swab head,
The sample size can be divided into three parts for testing and reserve samples respectively to meet the testing needs.
Scope of application:
Suspected cases, disease control testing, preferred by P3 laboratory
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